Clocinnamox mesylate

Cat. No. 0898

Clocinnamox mesylate C29H29ClN2O4.CH3SO3H [117332-69-1]

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Alternative Names: NIH 10443, C-CAM

Chemical Name: 14β-(p-Chlorocinnamoylamino)-7,8-dihydro-N-cyclopropylmethylmorphinone mesylate

Biological Activity

Systemically active, irreversible μ-opioid receptor antagonist (apparent Ki values are 0.7, 1.9 and 5.7 nM for mouse μ, δ and κ receptors respectively).

Technical Data

M.Wt:
601.11
Formula:
C29H29ClN2O4.CH3SO3H
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
117332-69-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Broadbear et al (2000) Methocinnamox is a potent, long-lasting, and selective antagonist of morphine-mediated antinociception in the mouse: comparison with clocinnamox, β-funaltrexamine, and β-chlornaltrexamine. J.Pharmacol.Exp.Ther. 294 933. PMID: 10945843.

Zernig et al (1996) Mechanism of clocinnamox blockade of opioid receptors: evidence from in vitro and ex vivo binding and behavioural assays. J.Pharmacol.Exp.Ther. 279 23. PMID: 8858971.

Burke et al (1994) Irreversible opioid antagonist effects of clocinnamox on opioid analgesia and mu receptor binding in mice. J.Pharmacol.Exp.Ther. 271 715. PMID: 7965787.

Aceto et al (1989) Very long-acting narcotic antagonists. The 14β-p-substituted cinnamoylaminomorphinones and their partial mu agonist codeinone relatives. Arzneimittelforschung 39 570. PMID: 2547389.

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Keywords: Clocinnamox mesylate, supplier, irreversible, mu-opioids, m-opioids, μ-opioids, receptors, antagonists, Tocris Bioscience, μ Opioid Receptor Antagonist products

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