10Panx

Cat. No. 3348

10Panx Trp-Arg-Gln-Ala-Ala-Phe-Val-Asp-Ser-Tyr

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Biological Activity

Panx-1 mimetic inhibitory peptide that blocks pannexin-1 gap junctions. Inhibits P2X7-mediated dye uptake, ATP-mediated IL-1β release and caspase-1 activation without altering membrane current in macrophages in vitro. Also blocks activation of NMDA receptor secondary currents (I2nd) by > 70%.

Technical Data

M.Wt:
1242.37
Formula:
C58H79N15O16
Sequence:
WRQAAFVDSY
Solubility:
Soluble to 1 mg/ml in 20mM PBS buffer with gentle warming
Storage:
Store at -20°C
CAS No:
955091-53-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Thompson et al (2008) Activation of pannexin-1 hemichannels augments aberrant bursting in the hippocampus. Science 322 1555. PMID: 19056988.

Wang et al (2007) Modulation of membrane channel currents by gap junction protein mimetic peptides: size matters. Am.J.Physiol.Cell Physiol. 293 C1112. PMID: 17652431.

Pelegrin and Surprenant (2006) Pannexin-1 mediates large pore formation and interleukin-1β; release by the ATP-gated P2X7 receptor. EMBO J. 25 5071. PMID: 17036048.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for 10Panx include:

Adamczyk et al (2015) P2X7 receptor activation regulates rapid unconventional export of transglutaminase-2. J Cell Sci 128 4615. PMID: 26542019.

Kowal et al (2015) Bile acid effects are mediated by ATP release and purinergic signalling in exocrine pancreatic cells. Cell Metab 13 28. PMID: 26050734.

Manohar et al (2012) ATP release and autocrine signaling through P2X4 receptors regulate γδ T cell activation. J Leukoc Biol 92 787. PMID: 22753954.

Do you know of a great paper that uses 10Panx from Tocris? If so please let us know.

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Keywords: 10Panx, supplier, Panx-1, mimetic, inhibitory, peptide, blocks, pannexin-1, gap, junctions, Connexins, Channels, modulators, Tocris Bioscience, Gap Channel Blocker products

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