Cat. No. 3348
Biological ActivityPanx-1 mimetic inhibitory peptide that blocks pannexin-1 gap junctions. Inhibits P2X7-mediated dye uptake, ATP-mediated IL-1β release and caspase-1 activation without altering membrane current in macrophages in vitro. Also blocks activation of NMDA receptor secondary currents (I2nd) by > 70%.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Thompson et al (2008) Activation of pannexin-1 hemichannels augments aberrant bursting in the hippocampus. Science 322 1555. PMID: 19056988.
Wang et al (2007) Modulation of membrane channel currents by gap junction protein mimetic peptides: size matters. Am.J.Physiol.Cell Physiol. 293 C1112. PMID: 17652431.
Pelegrin and Surprenant (2006) Pannexin-1 mediates large pore formation and interleukin-1β; release by the ATP-gated P2X7 receptor. EMBO J. 25 5071. PMID: 17036048.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for 10Panx include:
Adamczyk et al (2015) P2X7 receptor activation regulates rapid unconventional export of transglutaminase-2. J Cell Sci 128 4615. PMID: 26542019.
Manohar et al (2012) ATP release and autocrine signaling through P2X4 receptors regulate γδ T cell activation. J Leukoc Biol 92 787. PMID: 22753954.
Do you know of a great paper that uses 10Panx from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: 10Panx, supplier, Panx-1, mimetic, inhibitory, peptide, blocks, pannexin-1, gap, junctions, Connexins, Channels, modulators, Tocris Bioscience, Gap Channel Blocker products
Find multiple products by catalog number
New Products in this Area
Activator of STING-dependent signaling3',3'-cGAMP sodium salt
STING agonist2',3'-cGAMP sodium salt
Endogenous high affinity STING agonistc-Di-AMP sodium salt
Endogenous STING and DDX41 agonist; activates STING-dependent signalingc-Di-GMP sodium salt
Endogenous STING and DDX41 agonist; activates STING-dependent signalingCPYPP
DOCK2-Rac1 interaction inhibitor
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.