SNAP 94847 hydrochloride

Cat. No. 3347

SNAP 94847 hydrochloride C29H32F2N2O2.HCl [487051-12-7]

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Chemical Name: N-[3-[1-[[4-(3,4-Difluorophenoxy)phenyl]methyl]-4-piperidinyl]-4-methylphenyl]-2-methylpropanamide hydrochloride

Biological Activity

Potent melanin-concentrating hormone receptor 1 (MCH1) antagonist (Ki = 2.2 nM, KD = 530 pM) that displays > 80-fold and > 500-fold selectivity over α1A and D2 receptors respectively. Increases neurogenesis in the dentate gyrus and decreases food-reinforced operant responding in vivo. Exhibits anxiolytic activity and is orally active.

Technical Data

M.Wt:
515.03
Formula:
C29H32F2N2O2.HCl
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
487051-12-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Nair et al (2009) Effects of the MCH1 receptor antagonist SNAP 94847 on high-fat food-reinforced operant responding and reinstatement of food seeking in rats. Psychopharmacology 205 129. PMID: 19340414.

Chen et al (2007) Synthesis and SAR investigations for novel melanin-concentrating hormone 1 receptor (MCH1) antagonists part 2: A hybrid strategy combining key features of HTS hits. J.Med.Chem. 50 3883. PMID: 17668922.

David et al (2007) Efficacy of the MCHR1 antagonist N-[3-(1-{[4-(3,4-difluorophenoxy)phenyl]methyl}(4-piperidyl))-4-methylphenyl]-2-methylpropanamide (SNAP 94847) in mouse models of anxiety and depression following acute and chronic administration is independent of hippocampal neurogenesis. J.Pharmacol.Exp.Ther. 321 237. PMID: 17237257.

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Keywords: SNAP 94847 hydrochloride, supplier, Potent, selective, MCH1, antagonists, Melanin-concentrating, Hormone, Receptors, SNAP94847, hydrochloride, MCHR1, MCH1R, Tocris Bioscience, Melanin-concentrating Hormone Receptor Antagonist products

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