ATC 0175 hydrochloride

Cat. No. 3346

ATC 0175 hydrochloride C23H25F2N5O.HCl [510733-97-8]

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Chemical Name: N-[cis-4-[[4-(Dimethylamino)-2-quinazolinyl]amino]cyclohexyl]-3,4-difluorobenzamide hydrochloride

Biological Activity

Potent, selective and orally active melanin-concentrating hormone receptor 1 (MCH1) antagonist (IC50 values are 13.5 and > 10000 nM for MCH1 and MCH2 receptors respectively). Exhibits anxiolytic and antidepressant activity in rodents. Also displays affinity for 5-HT2B and 5-HT1A receptors (IC50 values are 9.66 and 16.9 nM respectively).

Technical Data

M.Wt:
461.94
Formula:
C23H25F2N5O.HCl
Solubility:
Soluble to 10 mM in DMSO and to 25 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
510733-97-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Chaki et al (2005) Anxiolytic- and antidepressant-like profile of ATC0065 and ATC0175: nonpeptidic and orally active melanin-concentrating hormone receptor 1 antagonists. J.Pharmacol.Exp.Ther. 313 831. PMID: 15677346.

Chaki et al (2005) ATC0175: an orally active melanin-concentrating hormone receptor 1 antagonist for the potential treatment of depression and anxiety. CNS Drug Rev. 11 341. PMID: 16614734.

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Keywords: ATC 0175 hydrochloride, supplier, MCH1, melanin, concentrating, hormone, receptors, 5-HT, serotonin, antagonists, ATC0175, hydrochloride, 5-HT2b, 5-HT1a, partial, MCHR1, MCH1R, Tocris Bioscience, Melanin-concentrating Hormone Receptor Antagonist products

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