SLV 320

Cat. No. 3344

SLV 320 C18H20N4O [251945-92-3]

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Chemical Name: trans-4-[(2-Phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexanol

Biological Activity

Potent and selective adenosine A1 receptor antagonist (Ki values are 1, 200, 398 and 3981 nM at human A1, A3, A2A and A2B receptors respectively). Suppresses cardiac fibrosis and attenuates albuminuria, without effect on blood pressure in animal models of chronic renal failure. Orally active.

Technical Data

M.Wt:
308.38
Formula:
C18H20N4O
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
251945-92-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Kalk et al (2007) The adenosine A1 receptor antagonist SLV320 reduces myocardial fibrosis in rats with 5/6 nephrectomy without effecting blood pressure. Br.J.Pharmacol. 151 1025. PMID: 17558436.

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Keywords: SLV 320, supplier, Potent, selective, A1, antagonists, Receptors, adenosines, SLV320, Tocris Bioscience, Adenosine A1 Receptor Antagonist products

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