Cat. No. 3344
Chemical Name: trans-4-[(2-Phenyl-7H-pyrrolo[2,3-d
Biological ActivityPotent and selective adenosine A1 receptor antagonist (Ki values are 1, 200, 398 and 3981 nM at human A1, A3, A2A and A2B receptors respectively). Suppresses cardiac fibrosis and attenuates albuminuria, without effect on blood pressure in animal models of chronic renal failure. Orally active.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Kalk et al (2007) The adenosine A1 receptor antagonist SLV320 reduces myocardial fibrosis in rats with 5/6 nephrectomy without effecting blood pressure. Br.J.Pharmacol. 151 1025. PMID: 17558436.
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Keywords: SLV 320, supplier, Potent, selective, A1, antagonists, Receptors, adenosines, SLV320, Tocris Bioscience, Adenosine A1 Receptor Antagonist products
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