Ro 8-4304 hydrochloride
Cat. No. 3343
Chemical Name: 4-[3-[4-(4-Fluorophenyl)-1,2,3,6-te
Biological ActivityNMDA receptor antagonist (IC50 = 0.4 μM) that displays > 100 fold selectivity for NR2B-containing receptors over NR2A-containing receptors. Exhibits an activity-dependent mechanism of NMDA antagonism and is competitive with respect to spermine (Cat. No. 0958).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Kew et al (1998) State-dependent NMDA receptor antagonism by Ro 8-4304, a novel NR2B selective, non-competitive, voltage-independent antagonist. Br.J.Pharmacol. 123 463. PMID: 9504387.
Kew and Kemp (1998) An allosteric interaction between the NMDA receptor polyamine and ifenprodil sites in rat cultured cortical neurones. J.Physiol. 512 17. PMID: 9729614.
If you know of a relevant reference for Ro 8-4304 hydrochloride please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses Ro 8-4304 hydrochloride from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: Ro 8-4304 hydrochloride, supplier, NR2B, selective, antagonists, NMDA, Receptors, Glutamate, Ionotropic, N-Methyl-D-Aspartate, iGluR, Ro8-4304, Tocris Bioscience, NMDA Receptor Antagonist products