L-798,106

Cat. No. 3342

L-798,106 C27H22BrNO4S [244101-02-8]

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Chemical Name: N-[(5-Bromo-2-methoxyphenyl)sulfonyl]-3-[2-(2-naphthalenylmethyl)phenyl]-2-propenamide

Biological Activity

Potent and highly selective prostanoid EP3 receptor antagonist (Ki values are 0.3, 916, > 5000 and > 5000 nM at EP3, EP4, EP1 and EP2 respectively). Attenuates sulprostone-induced inhibition of EFS-evoked twitch and contractile responses in vivo.

Technical Data

M.Wt:
536.44
Formula:
C27H22BrNO4S
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
244101-02-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Bassil et al (2008) Activation of prostaglandin EP receptors by lubiprostone in rat and human stomach and colon. Br.J.Pharmacol. 154 126. PMID: 18332851.

Clarke et al (2004) E-ring 8-isoprostanes inhibit ACh release from parasympathetic nerves innervating guinea-pig trachea through agonism of prostanoid receptors of the EP3-subtype. Br.J.Pharmacol. 141 600. PMID: 14744812.

Juteau et al (2001) Structure-activity relationships of cinnamic acylsulfonamide analogues on human EP3 prostanoid receptor. Bioorg.Med.Chem. 9 1977. PMID: 11504634.

If you know of a relevant reference for L-798,106 please let us know.

Citations are publications that use Tocris products. Selected citations for L-798,106 include:

Yang et al (2015) Exposure to 50 Hz magnetic field modulates GABAA currents in cerebellar granule neurons through an EP receptor-mediated PKC pathway. J Cell Mol Med 19 2413. PMID: 26176998.

Fernández-Galilea et al (2012) Effects of lipoic acid on lipolysis in 3T3-L1 adipocytes. J Lipid Res 53 2296. PMID: 22941773.

Tunaru et al (2012) Castor oil induces laxation and uterus contraction via ricinoleic acid activating prostaglandin EP3 receptors. Cell Commun Signal 109 9179. PMID: 22615395.

Chia et al (2011) Protection of protease-activated receptor 2 mediated vasodilatation against angiotensin II-induced vascular dysfunction in mice. BMC Pharmacol 11 10. PMID: 21955547.

Do you know of a great paper that uses L-798,106 from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: L-798,106, supplier, Potent, selective, EP3, antagonists, Receptors, Prostanoid, prostaglandins, prostacyclins, eicosanoids, L798106, Tocris Bioscience, Prostanoid Receptor Antagonist products

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