Cat. No. 3341
Chemical Name: N-(4-Ethoxyphenyl)-4-(2-methylimida
Biological ActivityPotent downstream hedgehog (Hh) signaling inhibitor that prevents Gli-dependent transcriptional activity (IC50 = 30 nM). Exhibits antiproliferative activity in a range of cancer cell lines (GI50 = 3 - 21 nM) and in human xenografts in vivo. Inhibits alcohol dehydrogenase 7 (Adh7) (IC50 = 210 nM) and acts as a microtubule depolymerizing agent in vitro.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Cupido et al (2009) The imidazopyridine derivative JK184 reveals dual roles for microtubules in hedgehog signaling. Angew.Chem.Int.Ed.Engl. 48 2321. PMID: 19222062.
Lee et al (2007) A small-molecule antagonist of the hedgehog signaling pathway. Chembiochem. 8 1916. PMID: 17886323.
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Keywords: JK 184, supplier, Alcohol, dehydrogenase, 7, inhibitors, inhibits, downstream, Hh, signaling, pathway, Signalling, Hedgehog, Gli, JK184, stem, cells, Tocris Bioscience, Aldehyde Dehydrogenase Inhibitor products