JK 184

Cat. No. 3341

JK 184 C19H18N4OS [315703-52-7]

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Chemical Name: N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-2-thiazolamine

Biological Activity

Potent downstream hedgehog (Hh) signaling inhibitor that prevents Gli-dependent transcriptional activity (IC50 = 30 nM). Exhibits antiproliferative activity in a range of cancer cell lines (GI50 = 3 - 21 nM) and in human xenografts in vivo. Inhibits alcohol dehydrogenase 7 (Adh7) (IC50 = 210 nM) and acts as a microtubule depolymerizing agent in vitro.

Technical Data

M.Wt:
350.44
Formula:
C19H18N4OS
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
315703-52-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Cupido et al (2009) The imidazopyridine derivative JK184 reveals dual roles for microtubules in hedgehog signaling. Angew.Chem.Int.Ed.Engl. 48 2321. PMID: 19222062.

Lee et al (2007) A small-molecule antagonist of the hedgehog signaling pathway. Chembiochem. 8 1916. PMID: 17886323.

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Keywords: JK 184, supplier, Alcohol, dehydrogenase, 7, inhibitors, inhibits, downstream, Hh, signaling, pathway, Signalling, Hedgehog, Gli, JK184, stem, cells, Tocris Bioscience, Aldehyde Dehydrogenase Inhibitor products

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