Cilostamide

Cat. No. 0915

Cilostamide C20H26N2O3 [68550-75-4]

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Alternative Name: OCP 3689

Chemical Name: N-Cyclohexyl-N-methyl-4-(1,2-dihydro-2-oxo-6-quinolyloxy)butyramide

Biological Activity

Selective inhibitor of type III phosphodiesterase (PDE3). Displays moderate selectivity for PDE3A isozyme vs. PDE3B (IC50 values are 0.027 and 0.050 μM for PDE3A and PDE3B respectively). Inhibits ADP-induced platelet aggregation (IC50 = 16.8 μM); antithrombotic. Also available as part of the Phosphodiesterase Inhibitor Tocriset™.

Technical Data

M.Wt:
342.44
Formula:
C20H26N2O3
Solubility:
Soluble to 100 mM in DMSO
Storage:
Store at RT
CAS No:
68550-75-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Sudo et al (2000) Potent effects of novel anti-platelet aggregatory cilostamide analogues on recombinant cyclic nucleotide phosphodiesterase isozyme activity. Biochem.Pharmacol. 59 347. PMID: 10644042.

Christensen and Torphy (1994) Isozyme-selective phosphodiesterase inhibitors as antiasthmatic agents. Annu.Rep.Med.Chem. 29 185.

Hidaki et al (1979) Selective inhibitor of platelet cyclic adenosine monophosphate phosphodiesterase, cilostamide, inhibits platelet aggregation. J.Pharmacol.Exp.Ther. 211 26. PMID: 226672.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Cilostamide include:

Ørstavik et al (2015) The inotropic effect of the active metabolite of levosimendan, OR-1896, is mediated through inhibition of PDE3 in rat ventricular myocardium. J Biol Chem 10 e0115547. PMID: 25738589.

Merino et al (2015) Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with Isoproterenol. PLoS One 10 e0132884. PMID: 26222156.

Brunet et al (2013) Increased intracellular magnesium attenuates β-adrenergic stimulation of the cardiac Ca(V)1.2 channel. J Gen Physiol 141 85. PMID: 23250865.

Zhai et al (2012) β-Adrenergic cAMP signals are predominantly regulated by phosphodiesterase type 4 in cultured adult rat aortic smooth muscle cells. PLoS One 7 e47826. PMID: 23094097.

Do you know of a great paper that uses Cilostamide from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Cilostamide, supplier, PDE3, inhibitors, inhibits, Phosphodiesterases, OCP3689, Tocris Bioscience, Phosphodiesterase Inhibitor products

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