Cat. No. 0915
Alternative Name: OCP 3689
Chemical Name: N-Cyclohexyl-N-methyl-4-(1,2-dihydr
Biological ActivitySelective inhibitor of type III phosphodiesterase (PDE3). Displays moderate selectivity for PDE3A isozyme vs. PDE3B (IC50 values are 0.027 and 0.050 μM for PDE3A and PDE3B respectively). Inhibits ADP-induced platelet aggregation (IC50 = 16.8 μM); antithrombotic. Also available as part of the Phosphodiesterase Inhibitor Tocriset™.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Sudo et al (2000) Potent effects of novel anti-platelet aggregatory cilostamide analogues on recombinant cyclic nucleotide phosphodiesterase isozyme activity. Biochem.Pharmacol. 59 347. PMID: 10644042.
Christensen and Torphy (1994) Isozyme-selective phosphodiesterase inhibitors as antiasthmatic agents. Annu.Rep.Med.Chem. 29 185.
Hidaki et al (1979) Selective inhibitor of platelet cyclic adenosine monophosphate phosphodiesterase, cilostamide, inhibits platelet aggregation. J.Pharmacol.Exp.Ther. 211 26. PMID: 226672.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for Cilostamide include:
Brunet et al (2013) Increased intracellular magnesium attenuates β-adrenergic stimulation of the cardiac Ca(V)1.2 channel. J Gen Physiol 141 85. PMID: 23250865.
Zhai et al (2012) β-Adrenergic cAMP signals are predominantly regulated by phosphodiesterase type 4 in cultured adult rat aortic smooth muscle cells. PLoS One 7 e47826. PMID: 23094097.
Do you know of a great paper that uses Cilostamide from Tocris? If so please let us know.
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Keywords: Cilostamide, supplier, PDE3, inhibitors, inhibits, Phosphodiesterases, OCP3689, Tocris Bioscience, Phosphodiesterase Inhibitor products
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