CID 755673

Cat. No. 3327

CID 755673 C12H11NO3 [521937-07-5]

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Chemical Name: 2,3,4,5-Tetrahydro-7-hydroxy-1H-benzofuro[2,3-c]azepin-1-one

Biological Activity

Selective protein kinase D (PKD) inhibitor (IC50 values are 0.182, 0.280, 0.227, >10, 15.3, 20.3, 40.5 and >50 μM at PKD1, PKD2, PKD3, PKC, CAK, PLK1, CAMKIIα and Akt respectively). Blocks PKD-mediated protein transport and inhibits prostate cancer cell proliferation, migration and invasion in vitro.

Technical Data

M.Wt:
217.22
Formula:
C12H11NO3
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
521937-07-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Sharlow et al (2008) Potent and selective disruption of protein kinase D functionality by benzoxoloazepinolone. J.Biol.Chem. 283 33516. PMID: 18829454.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for CID 755673 include:

Xu et al (2015) GPCR-mediated PLCβγ/PKCβ/PKD signaling pathway regulates the cofilin phosphatase slingshot 2 in neutrophil chemotaxis. Biochem Biophys Res Commun 26 874. PMID: 25568344.

Kienzle et al (2013) PKD controls mitotic Golgi complex fragmentation through a Raf-MEK1 pathway. Mol Biol Cell 24 222. PMID: 23242995.

Rezaee et al (2013) Sustained protein kinase D activation mediates respiratory syncytial virus-induced airway barrier disruption. J Virol 87 11088. PMID: 23926335.

Bhattacharya et al (2011) Bcr-abl signals to desensitize chronic myeloid leukemia cells to IFNα via accelerating the degradation of its receptor. Blood 118 4179. PMID: 21821707.

Qureshi et al (2011) Role of sphingomyelin synthase in controlling the antimicrobial activity of neutrophils against Cryptococcus neoformans. PLoS One 5 e15587. PMID: 21203393.

Spratley et al (2011) Protein kinase D regulates cofilin activity through p21-activated kinase 4. Sci Signal 286 34254. PMID: 21832093.

Subathra et al (2011) Sphingomyelin synthases regulate protein trafficking and secretion. PLoS One 6 e23644. PMID: 21980337.

Torres-Marquez et al (2010) CID755673 enhances mitogenic signaling by phorbol esters, bombesin and EGF through a protein kinase D-independent pathway. J Biol Chem 391 63. PMID: 19896460.

Do you know of a great paper that uses CID 755673 from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: CID 755673, supplier, Selective, protein, kinases, D, inhibitors, inhibits, PKD, CID755673, Tocris Bioscience, Protein Kinase D Inhibitor products

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