BGC 20-761

Cat. No. 3326

BGC 20-761 C19H22N2O [17375-63-2]

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Chemical Name: 5-Methoxy-N,N-dimethyl-2-phenyl-1H-indole-3-ethanamine

Biological Activity

Selective, high affinity 5-HT6 antagonist (Ki = 20 nM). Reverses the amnesic effects of scopolamine (Cat. No. 1414) and enhances memory consolidation in a rat model.

Technical Data

M.Wt:
294.39
Formula:
C19H22N2O
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
17375-63-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Mitchell et al (2006) BGC20-761, a novel tryptamine analog, enhances memory consolidation and reverses scopolamine-induced memory deficit in social and visuospatial memory tasks through a 5-HT6 receptor-mediated mechanism. Neuropharmacology 50 412. PMID: 16298400.

Glennon et al (2000) 2-substituted tryptamines: agents with selectivity for 5-HT6 serotonin receptors. J.Med.Chem. 43 1011. PMID: 10715164.

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Keywords: BGC 20-761, supplier, 5ht, 5-hydroxytryptamine, serotonin, 5ht6, high, affinity, ligands, BGC20761, Tocris Bioscience, 5-HT6 Receptor Antagonist products

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