Cat. No. 3324
Chemical Name: (2S)-2-[2-(Indan-5-yloxy)-9-(1,1'-bi
Biological ActivityGTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor. Modulates ARF-GTP levels and synergizes with the Wnt/β-catenin signaling pathway to upregulate β-catenin nuclear translocation. Also reduces in vitro migration of metastatic human breast cancer cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Emre et al (2007) A chemical approach to stem cell biology Curr.Opin.Chem.Biol. 11 252. PMID: 17493865 .
Zhang et al (2007) Small-molecule synergist of the Wnt/β-catenin signaling pathway. Proc.Natl.Acad.Sci.USA 104 7444. PMID: 17460038.
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Citations are publications that use Tocris products. Selected citations for QS 11 include:
Wu, J et al (2016) Co-regulation of the Notch and Wnt signaling pathways promotes supporting cell proliferation and hair cell regeneration in mouse utricles Scientific Reports 6 29418 . PMID: 27435629.
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Keywords: QS 11, supplier, QS11, ARFGAP1, inhibitor, inhibits, modulator, Wnt, signaling, signalling, ADP-ribosylation, factor, 1, inhibitors, Tocris Bioscience, G Protein (Small) Inhibitor products