Cat. No. 3324
Chemical Name: (2S)-2-[2-(Indan-5-yloxy)-9-(1,1'-bi
Biological ActivityGTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor. Modulates ARF-GTP levels and synergizes with the Wnt/β-catenin signaling pathway to upregulate β-catenin nuclear translocation. Also reduces in vitro migration of metastatic human breast cancer cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Emre et al (2007) A chemical approach to stem cell biology Curr.Opin.Chem.Biol. 11 252. PMID: 17493865 .
Zhang et al (2007) Small-molecule synergist of the Wnt/β-catenin signaling pathway. Proc.Natl.Acad.Sci.USA 104 7444. PMID: 17460038.
If you know of a relevant reference for QS 11 please let us know.
Citations are publications that use Tocris products. Selected citations for QS 11 include:
Wu, J et al (2016) Co-regulation of the Notch and Wnt signaling pathways promotes supporting cell proliferation and hair cell regeneration in mouse utricles Scientific Reports 6 29418 . PMID: 27435629.
Do you know of a great paper that uses QS 11 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: QS 11, supplier, QS11, ARFGAP1, inhibitor, inhibits, modulator, Wnt, signaling, signalling, ADP-ribosylation, factor, 1, inhibitors, Tocris Bioscience, G Protein (Small) Inhibitor products
Find multiple products by catalog number
New Products in this Area
Cx43 hemichannel blockerWL 47 - dimer
High affinity caveolin-1 ligandSAG 21k
Hedgehog signaling activator; brain penetrant and orally bioavailable
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.