ZD 9379

Cat. No. 3322

ZD 9379 C19H14ClN3O4 [170142-20-8]

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Chemical Name: 7-Chloro-2,3-dihydro-2-(4-methoxy-2-methylphenyl)pyridazino [4,5-b] quinoline-1,4,10(5H)trione

Biological Activity

NMDA receptor antagonist; acts at glycine site. Neuroprotective; reduces infarct size and frequency of spreading depressions in a rat model of ischemic stroke. Brain penetrant.

Licensing Information

Sold for research purposes under agreement from AstraZeneca

Technical Data

M.Wt:
383.79
Formula:
C19H14ClN3O4
Solubility:
Soluble to 50 mM in DMSO and to 20 mM in 1eq. NaOH
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
170142-20-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Tatlisumak (2000) A glycine antagonist ZD9379 reduces number of spreading depressions and infarct size in rats with permanent middle cerebral artery occlusion. Acta.Neurochir.Suppl. 76 331. PMID: 11450037.

Takano (1997) Glycine site antagonist attenuates infarct size in experimental focal ischemia. Postmortem and diffusion mapping studies. Stroke. 28 1255. PMID: 9183359.

Bare (1993) Pyridazino[4,5-b]quinolinediones: a series of novel glycine site NMDA antagonists with potent in vitro and in vivo properties. Abstracts of Papers of the ACS 205 79. Abstract..

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Keywords: ZD 9379, supplier, ZD9379, glycine, antagonists, NMDA, neuroprotectives, brain, penetrant, Tocris Bioscience, NMDA Receptor Antagonist products

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