AR-C 66096 tetrasodium salt

Cat. No. 3321

AR-C 66096 tetrasodium salt C14H18F2N5Na4O12P3S [145782-74-7]

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Alternative Names: FPL 66096, ARL 66096

Chemical Name: 2-(Propylthio)adenosine-5'-O-(β,γ-difluoromethylene)triphosphate tetrasodium salt

Biological Activity

Potent and selective P2Y12 receptor antagonist. Blocks ADP-induced inhibition of adenylyl cyclase in vitro (pKB =7.6) and inhibits ADP-induced aggregation of washed human platelets (pIC50 = 8.16).

Licensing Information

Sold for research purposes under agreement from AstraZeneca

Technical Data

M.Wt:
703.26
Formula:
C14H18F2N5Na4O12P3S
Solubility:
Soluble in water (supplied pre-dissolved at a concentration of 10mM)
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
145782-74-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Simon et al (2001) Activity of adenosine diphosphates and triphosphates on a P2YT-type receptor in brain capillary endothelial cells. Br.J.Pharmacol. 132 173. PMID: 11156575.

Ingall et al (1999) Antagonists of the platelet P receptor: a novel approach to antithrombotic therapy. J.Med.Chem. 42 213. PMID: 9925726.

Humphries et al (1994) FPL 66096: a novel, highly potent and selective antagonist at human platelet P2T-purinoceptors. Br.J.Pharmacol. 113 1057. PMID: 7858849.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for AR-C 66096 tetrasodium salt include:

Helms et al (2013) Mechanisms of hemolysis-associated platelet activation. J Thromb Haemost 11 2148. PMID: 24119131.

Pinheiro et al (2013) Bradykinin-induced Ca2+ signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y12 receptors activation. Cell Commun Signal 11 70. PMID: 24047499.

Do you know of a great paper that uses AR-C 66096 tetrasodium salt from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: AR-C 66096 tetrasodium salt, supplier, FPL66096, AR-C66096, ARC66096, potent, selective, p2y12, purine, receptors, antagonist, purinoceptors, purinergic, p2yt, ARL66096, AstraZeneca, Tocris Bioscience, Purinergic (P2Y) Receptor Antagonist products

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