AR-C 66096 tetrasodium salt
Cat. No. 3321
Alternative Names: FPL 66096, ARL 66096
Chemical Name: 2-(Propylthio)adenosine-5'-O-(β,γ-difl
Biological ActivityPotent and selective P2Y12 receptor antagonist. Blocks ADP-induced inhibition of adenylyl cyclase in vitro (pKB =7.6) and inhibits ADP-induced aggregation of washed human platelets (pIC50 = 8.16).
Licensing InformationSold for research purposes under agreement from AstraZeneca
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Simon et al (2001) Activity of adenosine diphosphates and triphosphates on a P2YT-type receptor in brain capillary endothelial cells. Br.J.Pharmacol. 132 173. PMID: 11156575.
Ingall et al (1999) Antagonists of the platelet P receptor: a novel approach to antithrombotic therapy. J.Med.Chem. 42 213. PMID: 9925726.
Humphries et al (1994) FPL 66096: a novel, highly potent and selective antagonist at human platelet P2T-purinoceptors. Br.J.Pharmacol. 113 1057. PMID: 7858849.
If you know of a relevant reference for AR-C 66096 tetrasodium salt please let us know.
Citations are publications that use Tocris products. Selected citations for AR-C 66096 tetrasodium salt include:
Zhang et al (2014) Agonist-bound structure of the human P2Y12 receptor. Purinergic Signal 509 119. PMID: 24784220.
Gao et al (2013) The role of P2Y(14) and other P2Y receptors in degranulation of human LAD2 mast cells. Cell Commun Signal 9 31. PMID: 22825617.
Helms et al (2013) Mechanisms of hemolysis-associated platelet activation. J Thromb Haemost 11 2148. PMID: 24119131.
Pinheiro et al (2013) Bradykinin-induced Ca2+ signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y12 receptors activation. Cell Commun Signal 11 70. PMID: 24047499.
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