Cat. No. 1055
Biological ActivityEndogenous peptide with an exceptionally high affinity (Ki = 360 pM) and selectivity for μ opioid receptors (4000- and 15000-fold preference over δ and κ respectively).
(Modifications: Phe-3 = C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Goldberg et al (1998) Pharmacological characterization of endomorphin-1 and endomorphin-2 in mouse brain. J.Pharmacol.Exp.Ther. 286 1007. PMID: 9694962.
Harrison et al (1998) Differential effects of endomorphin-1, endomorphin-2, and tyr-W-MIF-1 on activation of G-proteins in SH-SY5Y human neuroblastoma membranes. Peptides 19 749. PMID: 9622031.
Kakizawa et al (1998) Parallel stimulations of in vitro and in situ [35S]GTPγS binding by endomorphin 1 and DAMGO in mouse brains. Peptides 19 755. PMID: 9622032.
Zadina et al (1997) A potent and selective endogenous agonist for the μ-opiate receptor. Nature 386 499. PMID: 9087409.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for Endomorphin-1 include:
Dortch-Carnes and Russell (2007) Morphine-stimulated nitric oxide release in rabbit aqueous humor. Am J Physiol Endocrinol Metab 84 185. PMID: 17094965.
Garzón et al (2004) RGSZ1 and GAIP regulate mu- but not delta-opioid receptors in mouse CNS: role in tachyphylaxis and acute tolerance. Neuropsychopharmacology 29 1091. PMID: 14997173.
Do you know of a great paper that uses Endomorphin-1 from Tocris? If so please let us know.
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Keywords: Endomorphin-1, supplier, Potent, selective, μ-opioid, mu-opioid, agonists, MOP, Receptors, OP3, Tocris Bioscience, μ Opioid Receptor Agonist products
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