RS 25344 hydrochloride

Cat. No. 3315

RS 25344 hydrochloride C19H13N5O4.HCl [152815-28-6]

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Chemical Name: 1-(3-Nitrophenyl)-3-(4-pyridinylmethyl)-pyrido[2,3-d]pyrimidine-2,3-(1H,3H)-dione hydrochloride

Biological Activity

Potent and selective phosphodiesterase (PDE) 4 inhibitor (IC50 values are 0.28, > 100, 160 and 330 nM at PDE4, PDE1, PDE2 and PDE3 respectively). Inhibits eosinophil chemotaxis and increases progressive motility of spermatozoa in vitro.

Technical Data

M.Wt:
411.8
Formula:
C19H13N5O4.HCl
Solubility:
Soluble to 50 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
152815-28-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Bajpai et al (2006) AKAP3 selectively binds PDE4A isoforms in bovine spermatozoa. Biol.Reprod. 74 109. PMID: 16177223.

Alvarez et al (1995) Activation and selective inhibition of a cyclic AMP-specific phosphodiesterase, PDE-4D3. Mol.Pharmacol. 48 616. PMID: 7476886.

Kaneko et al (1995) Elevated intracellular cyclic AMP inhibits chemotaxis in human eosinophils. Cell.Signal. 7 527. PMID: 8562314.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for RS 25344 hydrochloride include:

Boomkamp et al (2014) Epac and the high affinity rolipram binding conformer of PDE4 modulate neurite outgrowth and myelination using an in vitro spinal cord injury model. Cell Rep 171 2385. PMID: 24467222.

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Keywords: RS 25344 hydrochloride, supplier, RS25344, potent, PDE4, inhibitors, inhibits, phosphodiesterases, Tocris Bioscience, Phosphodiesterase Inhibitor products

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