RS 25344 hydrochloride

Cat. No. 3315

RS 25344 hydrochloride C19H13N5O4.HCl [152815-28-6]

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Chemical Name: 1-(3-Nitrophenyl)-3-(4-pyridinylmethyl)-pyrido[2,3-d]pyrimidine-2,3-(1H,3H)-dione hydrochloride

Biological Activity

Potent and selective phosphodiesterase (PDE) 4 inhibitor (IC50 values are 0.28, > 100, 160 and 330 nM at PDE4, PDE1, PDE2 and PDE3 respectively). Inhibits eosinophil chemotaxis and increases progressive motility of spermatozoa in vitro.

Technical Data

M.Wt:
411.8
Formula:
C19H13N5O4.HCl
Solubility:
Soluble to 50 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
152815-28-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Bajpai et al (2006) AKAP3 selectively binds PDE4A isoforms in bovine spermatozoa. Biol.Reprod. 74 109. PMID: 16177223.

Alvarez et al (1995) Activation and selective inhibition of a cyclic AMP-specific phosphodiesterase, PDE-4D3. Mol.Pharmacol. 48 616. PMID: 7476886.

Kaneko et al (1995) Elevated intracellular cyclic AMP inhibits chemotaxis in human eosinophils. Cell.Signal. 7 527. PMID: 8562314.

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Keywords: RS 25344 hydrochloride, supplier, RS25344, potent, PDE4, inhibitors, inhibits, phosphodiesterases, Tocris Bioscience, Phosphodiesterase Inhibitor products

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