Cat. No. 3313
Chemical Name: 5,7-Bis(1,1-dimethylethyl)-3-hydrox
Biological ActivityPotent and selective GABAB receptor positive allosteric modulator that increases the potency and efficacy of GABA ( > 15-fold and > 149% respectively). Exhibits anxiolytic activity in vivo and is orally active.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Koek et al (2013) Discriminative stimulus effects of the GABAB receptor-positive modulator rac-BHFF: comparison with GABAB receptor agonists and drugs of abuse. J.Pharmacol.Exp.Ther. 344 553. PMID: 23275067.
Malherbe et al (2008) Characterization of (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one as a positive allosteric modulator of GABAB receptors. Br.J.Pharmacol. 154 797. PMID: 18536733.
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Citations are publications that use Tocris products. Selected citations for rac BHFF include:
Zhang et al (2015) GABAB receptor upregulates fragile X mental retardation protein expression in neurons. Clin Exp Dermatol 5 10468. PMID: 26020477.
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Keywords: rac BHFF, supplier, Potent, selective, GABAB, positive, allosteric, modulators, Receptors, Tocris Bioscience, GABAB Receptor Modulator products
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