A23187, free acid

Cat. No. 1234

A23187, free acid C29H37N3O6 [52665-69-7]

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Alternative Name: Calcimycin

Chemical Name: 5-(Methylamino)-2-[[2R,3R,6S,8S,9R,11R) -3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)-ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-4-benzoxazolecarboxylic acid

Biological Activity

Calcium ionophore that induces Ca2+-dependent cell death by increasing intracellular calcium concentration. Promotes intracelllular ROS generation and platelet particle formation (fragmentation) in vitro and in vivo. Can be used to induce autophagy in mammalian cells.

Technical Data

M.Wt:
523.63
Formula:
C29H37N3O6
Solubility:
Soluble to 50 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at +4°C
CAS No:
52665-69-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Sakanashi et al (2009) Zn2+, derived from cell preparation, partly attenuates Ca2+-dependent cell death induced by A23187, calcium ionophore, in rat thymocytes. Toxicol.In Vitro 23 338. PMID: 19124067.

Ding et al (2007) Differential effects of endoplasmic reticulum stress-induced autophagy on cell survival. J.Biol.Chem. 282 4702. PMID: 17135238.

Kajitani et al (2007) Mechanism of A23187-induced apoptosis in HL-60 cells: dependency on mitochondrial permeability transition but not NADPH oxidase. Biosci.Biotechnol.Bichem. 71 2701. PMID: 7535265.

Nardi et al (2007) Platelet particle formation by anti-GPIIIa49-66 Ab, Ca2+ ionophore A23187, and phorbol myristate acetate is induced by reactive oxygen species and inhibited by dexamethasone blockade of platelet phospholipase A2, 12-lipoxygenase, and NADPH oxidase. Blood 110 1989. PMID: 17545506.

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Citations are publications that use Tocris products. Selected citations for A23187, free acid include:

Cahalan et al (2015) Piezo1 links mechanical forces to red blood cell volume. Cardiovasc Res 4. PMID: 26001274.

Díaz et al (2015) Biomechanical forces promote blood development through prostaglandin E2 and the cAMP-PKA signaling axis. J Exp Med 212 665. PMID: 25870199.

Harper and Poole (2013) Chloride channels are necessary for full platelet phosphatidylserine exposure and procoagulant activity. BMC Cancer 4 e969. PMID: 24357800.

Yung et al (2013) Activation of AMPK inhibits cervical cancer cell growth through AKT/FOXO3a/FOXM1 signaling cascade. Neuropharmacology 13 327. PMID: 23819460.

Arozarena et al (2011) Oncogenic BRAF induces melanoma cell invasion by downregulating the cGMP-specific phosphodiesterase PDE5A. Cancer Cell 19 45. PMID: 21215707.

Cheang et al (2011) Endothelial nitric oxide synthase enhancer reduces oxidative stress and restores endothelial function in db/db mice. Cell Death Dis 92 267. PMID: 21875904.

Do you know of a great paper that uses A23187, free acid from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: A23187, free acid, supplier, Calcium, ionophore, Ca2+, Ionophore, Signaling, Signalling, Agents, General, antibiotics, Tocris Bioscience, General Calcium Signaling Agent products

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