Fluvastatin sodium

Cat. No. 3309

Fluvastatin sodium C24H25FNNaO4 [93957-55-2]

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Chemical Name: (±)-(3R*,5S*,6E)-7-[3-(4-Fluorophenyl)-1-(1-methyethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid sodium salt

Biological Activity

Orally active, potent and competitive HMG-CoA reductase inhibitor (IC50 = 40 -100 nM at human liver microsomes). Inhibits vascular smooth muscle proliferation in vitro (IC50 = 70 nM) and exhibits antihypercholesterolemic and antioxidant activity in vivo.

Technical Data

M.Wt:
433.45
Formula:
C24H25FNNaO4
Solubility:
Soluble to 25 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at -20°C
CAS No:
93957-55-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Turner et al (2007) Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. J.Cardiovasc.Pharmacol. 50 458. PMID: 18049315.

Yamamoto et al (2001) Antioxidative effects of fluvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on peroxidation of phospholipid liposomes. J.Pharm.Pharmacol. 53 227. PMID: 11273020.

Dansette et al (2000) HMG-CoA reductase activity in human liver microsomes: comparative inhibition by statins. Exp.Toxicol.Pathol. 52 145. PMID: 10965989.

If you know of a relevant reference for Fluvastatin sodium please let us know.

Citations are publications that use Tocris products. Selected citations for Fluvastatin sodium include:

Vainio et al (2011) Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by statins. Am J Physiol Renal Physiol 2 1176. PMID: 22202492.

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Keywords: Fluvastatin sodium, supplier, HMG-CoA, reductases, inhibitors, inhibits, Tocris Bioscience, HMG-CoA Reductase Inhibitor products

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