Cytochalasin D

Cat. No. 1233

Cytochalasin D C30H37NO6 [22144-77-0]

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Alternative Name: Zygosporin A

Chemical Name: (7S,13E,16S,18R,19E,21R)-21-(Acetyloxy)- 7,18-dihydroxy-16,18-dimethyl-10-phenyl[11]cytochalasa-6(12),13,19-triene-1,17-dione

Biological Activity

Potent disruptor of actin filament function. Alters tight junction permeability. Unlike cytochalasin B (Cat. No. 5474), does not inhibit monosaccharide transport across the plasma membrane.

Technical Data

Soluble to 10 mM in ethanol with gentle warming and to 50 mM in DMSO
>95 %
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Abedi and Zachary (1998) Cytochalasin D stimulation of tyrosine phosphorylation and phosphotyrosine-associated kinase activity in vascular smooth muscle cells. Biochem.Biophys.Res.Commun. 245 646. PMID: 9588169.

Stevenson and Begg (1994) Concentration-dependent effects of cytochalasin D on tight junctions and actin filaments in MDCK epithelial cells. J.Cell Sci. 107 367. PMID: 8006058.

Carlier et al (1986) Interaction of cytochalasin D with actin filaments in the presence of ADP and ATP. J.Biol.Chem. 261 2041. PMID: 3944126.

If you know of a relevant reference for Cytochalasin D please let us know.

Citations are publications that use Tocris products. Selected citations for Cytochalasin D include:

Chambers et al (2015) Actin dynamics tune the integrated stress response by regulating eukaryotic initiation factor 2α dephosphorylation. Elife 4. PMID: 25774599.

Chen et al (2015) G-actin provides substrate-specificity to eukaryotic initiation factor 2α holophosphatases. Elife 4. PMID: 25774600.

Dobson et al (2015) Caffeine Modulates Vesicle Release and Recovery at Cerebellar Parallel Fibre Terminals, Independently of Calcium and Cyclic AMP Signalling. Elife 10 e0125974. PMID: 25933382.

Lopez-Escobar et al (2015) The effect of maternal diabetes on the Wnt-PCP pathway during embryogenesis as reflected in the developing mouse eye. Proc Natl Acad Sci U S A 8 157. PMID: 25540130.

Yang et al (2015) ICAM-1 suppresses tumor metastasis by inhibiting macrophage M2 polarization through blockade of efferocytosis. Am J Physiol Cell Physiol 6 e1780. PMID: 26068788.

Gault et al (2014) Osmotic surveillance mediates rapid wound closure through nucleotide release. J Cell Biol 207 767. PMID: 25533845.

Lee et al (2014) Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage. Cell Death Dis 111 E5114. PMID: 25385580.

Mora et al (2013) Recombinant probes reveal dynamic localization of CaMKIIα within somata of cortical neurons. J Neurosci 33 14579. PMID: 24005308.

Jeyaraj et al (2012) Cyclic AMP-Rap1A signaling activates RhoA to induce α(2c)-adrenoceptor translocation to the cell surface of microvascular smooth muscle cells. Integr Biol (Camb) 303 C499. PMID: 22621783.

Lin et al (2012) Curcumin inhibits glutamate release from rat prefrontal nerve endings by affecting vesicle mobilization. PLoS One 13 9097. PMID: 22942754.

Gjorevski and Nelson (2010) Endogenous patterns of mechanical stress are required for branching morphogenesis. Biochem Biophys Res Commun 2 424. PMID: 20717570.

Gomez et al (2010) Tissue geometry patterns epithelial-mesenchymal transition via intercellular mechanotransduction. Dis Model Mech 110 44. PMID: 20336666.

Bose and Thomas (2009) The actin cytoskeleton differentially regulates NG115-401L cell ryanodine receptor and inositol 1,4,5-trisphosphate receptor induced calcium signaling pathways. Int J Mol Sci 379 594. PMID: 19126405.

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Keywords: Cytochalasin D, supplier, Disrupts, actin, filament, function, CytochalasinD, ZygosporinA, Tocris Bioscience, Actin products

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