Cytochalasin D

Cat. No. 1233

Cytochalasin D C30H37NO6 [22144-77-0]

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Alternative Name: Zygosporin A

Chemical Name: (7S,13E,16S,18R,19E,21R)-21-(Acetyloxy)- 7,18-dihydroxy-16,18-dimethyl-10-phenyl[11]cytochalasa-6(12),13,19-triene-1,17-dione

Biological Activity

Potent disruptor of actin filament function. Alters tight junction permeability. Unlike cytochalasin B (Cat. No. 5474), does not inhibit monosaccharide transport across the plasma membrane.

Technical Data

M.Wt:
507.63
Formula:
C30H37NO6
Solubility:
Soluble to 10 mM in ethanol with gentle warming and to 50 mM in DMSO
Purity:
>95 %
Storage:
Desiccate at -20°C
CAS No:
22144-77-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Abedi and Zachary (1998) Cytochalasin D stimulation of tyrosine phosphorylation and phosphotyrosine-associated kinase activity in vascular smooth muscle cells. Biochem.Biophys.Res.Commun. 245 646. PMID: 9588169.

Stevenson and Begg (1994) Concentration-dependent effects of cytochalasin D on tight junctions and actin filaments in MDCK epithelial cells. J.Cell Sci. 107 367. PMID: 8006058.

Carlier et al (1986) Interaction of cytochalasin D with actin filaments in the presence of ADP and ATP. J.Biol.Chem. 261 2041. PMID: 3944126.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Cytochalasin D include:

Chambers et al (2015) Actin dynamics tune the integrated stress response by regulating eukaryotic initiation factor 2α dephosphorylation. Elife 4. PMID: 25774599.

Chen et al (2015) G-actin provides substrate-specificity to eukaryotic initiation factor 2α holophosphatases. Elife 4. PMID: 25774600.

Gault et al (2014) Osmotic surveillance mediates rapid wound closure through nucleotide release. J Cell Biol 207 767. PMID: 25533845.

Mora et al (2013) Recombinant probes reveal dynamic localization of CaMKIIα within somata of cortical neurons. J Neurosci 33 14579. PMID: 24005308.

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Keywords: Cytochalasin D, supplier, Disrupts, actin, filament, function, CytochalasinD, ZygosporinA, Tocris Bioscience, Actin products

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