Cat. No. 0875
Chemical Name: 1-(3-Chlorophenyl)piperazine hydrochloride
Biological Activity5-HT2C/2B receptor agonist/partial agonist; displays some activity at 5-HT2A and 5-HT1 receptors. pEC50 values are 7.09, 7.2, 6.65, 5.9 and 6.5 for human recombinant 5-HT2C, 2B and 2A, bovine 5-HT1A and rat 5-HT1B receptors respectively. Suppresses locomotor activity in rats in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Porter et al (1999) Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells. Br.J.Pharmacol. 128 13. PMID: 10498829.
Hoyer et al (1994) VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol.Rev. 46 157. PMID: 7938165.
Curzon et al (1990) m-CPP: a tool for studying behavioural responses associated with 5-HT1C receptors. TiPS 11 181. PMID: 2188399.
Lucki et al (1989) Effect of 1-(m-Chlorophenyl)piperazine and 1-(m-trifluoromethylphenyl)piperazine on locomotor activity. J.Pharmacol.Exp.Ther. 249 155. PMID: 2709329.
If you know of a relevant reference for m-CPP hydrochloride please let us know.
Citations are publications that use Tocris products. Selected citations for m-CPP hydrochloride include:
Moya et al (2011) Altered 5-HT2C receptor agonist-induced responses and 5-HT2C receptor RNA editing in the amygdala of serotonin transporter knockout mice. BMC Pharmacol 11 3. PMID: 21473759.
Do you know of a great paper that uses m-CPP hydrochloride from Tocris? If so please let us know.
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Keywords: m-CPP hydrochloride, supplier, 5-HT2B/2C, receptor, agonists, Serotonin, 5-HT2C, Receptors, 5-HT2B, Tocris Bioscience, 5-HT2B Receptor Agonist products
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July 8 - 12, 2017