Cat. No. 3306

8-(3-Chlorostyryl)caffeine C16H15ClN4O2 [147700-11-6]

Price and Availability

For 8-(3-Chlorostyryl)caffeine pricing & availability please select your country from the drop down menu:
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: CSC

Chemical Name: (E)-8-[2-(3-Chlorophenyl)ethenyl]-3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

Biological Activity

Selective adenosine A2A receptor antagonist and monoamine oxidase B (MAO-B) inhibitor (Ki values are 54 and 28200 nM at rat A2A and A1 receptors respectively and Ki ~ 100 nM at MAO-B). Potently protects against quinolinic acid-induced (Cat. No. 0225) neuronal damage and is neuroprotective in the MPTP model of Parkinson's disease.

Technical Data

Soluble to 25 mM in DMSO
>99 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Vlok et al (2006) Inhibition of monoamine oxidase B by analogues of the adenosine A2A receptor antagonist (E)-8-(3-chlorostyryl)caffeine (CSC). Bioorg.Med.Chem. 14 3512. PMID: 16442801.

Behan and Stone (2002) Enhanced neuronal damage by co-administration of quinolinic acid and free radicals, and protection by adenosine A2A receptor antagonists. Br.J.Pharmacol. 135 1435. PMID: 11906956.

Chen et al (2002) 8-(3-Chlorostyryl)caffeine may attenuate MPTP neurotoxicity through dual actions on monoamine oxidase inhibition and A2A receptor antagonism. J.Biol.Chem. 277 36040. PMID: 12130655.

If you know of a relevant reference for 8-(3-Chlorostyryl)caffeine please let us know.

Citations are publications that use Tocris products. Selected citations for 8-(3-Chlorostyryl)caffeine include:

Benada et al (2015) Polo-like kinase 1 inhibits DNA damage response during mitosis. Oncotarget 14 219. PMID: 25607646.

Li et al (2014) Regulation of photoreceptor gap junction phosphorylation by adenosine in zebrafish retina. Vis Neurosci 31 237. PMID: 24844306.

Factor et al (2007) Adenosine regulation of alveolar fluid clearance. Cell Cycle 104 4083. PMID: 17360481.

Do you know of a great paper that uses 8-(3-Chlorostyryl)caffeine from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: 8-(3-Chlorostyryl)caffeine, supplier, Selective, A2A, antagonists, MAO-B, inhibitors, inhibits, Receptors, adenosines, Monoamine, Oxygenases, Oxidases, Tocris Bioscience, Adenosine A2A Receptor Antagonist products

Quick Order

Find multiple products by catalog number

divider line

Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

Our Cardiovascular Guide highlights over 250 products for cardiovascular research. Request copy or view PDF today.

divider line

Neurodegeneration Research Product Guide

Neurodegeneration Product Guide

Our Neurodegeneration guide highlights over 275 products for neurodegeneration research. Request copy or view PDF today.

divider line

Pain Research Product Guide

Pain Research Product Guide

Our Pain guide highlights over 280 products for Pain research. Request copy or view PDF today.

divider line

GPCR Product Listing

GPCR Product Listing

Highlights over 450 products for GPCRs. Request copy or view PDF today.

divider line

Parkinson's Life Science Poster

Written by Anthony H.V. Schapira

Parkinson's Life Science Poster

Our Parkinson's disease (PD) poster summarizes the neurobiology of the disease, and highlights current therapeutic treatments for symptomatic PD. Request copy or view PDF today.

divider line

Cardiovascular Life Science Poster

Written by J.J. Maguire and A.P. Davenport

Cardiovascular Life Science Poster

Our Cardiovascular poster highlights the key G protein-coupled receptors involved in the regulation of vascular reactivity. Request copy or view PDF today.

divider line

New Products in this Area


High affinity adenosine A1 receptor antagonist

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.