Cat. No. 3306
Alternative Name: CSC
Chemical Name: (E)-8-[2-(3-Chlorophenyl)ethenyl]-3
Biological ActivitySelective adenosine A2A receptor antagonist and monoamine oxidase B (MAO-B) inhibitor (Ki values are 54 and 28200 nM at rat A2A and A1 receptors respectively and Ki ~ 100 nM at MAO-B). Potently protects against quinolinic acid-induced (Cat. No. 0225) neuronal damage and is neuroprotective in the MPTP model of Parkinson's disease.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Vlok et al (2006) Inhibition of monoamine oxidase B by analogues of the adenosine A2A receptor antagonist (E)-8-(3-chlorostyryl)caffeine (CSC). Bioorg.Med.Chem. 14 3512. PMID: 16442801.
Behan and Stone (2002) Enhanced neuronal damage by co-administration of quinolinic acid and free radicals, and protection by adenosine A2A receptor antagonists. Br.J.Pharmacol. 135 1435. PMID: 11906956.
Chen et al (2002) 8-(3-Chlorostyryl)caffeine may attenuate MPTP neurotoxicity through dual actions on monoamine oxidase inhibition and A2A receptor antagonism. J.Biol.Chem. 277 36040. PMID: 12130655.
If you know of a relevant reference for 8-(3-Chlorostyryl)caffeine please let us know.
Citations are publications that use Tocris products. Selected citations for 8-(3-Chlorostyryl)caffeine include:
Benada et al (2015) Polo-like kinase 1 inhibits DNA damage response during mitosis. Oncotarget 14 219. PMID: 25607646.
Li et al (2014) Regulation of photoreceptor gap junction phosphorylation by adenosine in zebrafish retina. Vis Neurosci 31 237. PMID: 24844306.
Factor et al (2007) Adenosine regulation of alveolar fluid clearance. Cell Cycle 104 4083. PMID: 17360481.
Do you know of a great paper that uses 8-(3-Chlorostyryl)caffeine from Tocris? If so please let us know.
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Keywords: 8-(3-Chlorostyryl)caffeine, supplier, Selective, A2A, antagonists, MAO-B, inhibitors, inhibits, Receptors, adenosines, Monoamine, Oxygenases, Oxidases, Tocris Bioscience, Adenosine A2A Receptor Antagonist products
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