Alfuzosin hydrochloride

Cat. No. 3305

Alfuzosin hydrochloride C19H27N5O4.HCl [81403-68-1]

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Chemical Name: N-[3-[(4-Amino-6,7-dimethoxy-2-quinazolinyl)methylamino]propyl]tetrahydro-2-furancarboxamide hydrochloride

Biological Activity

Functionally uro-selective α1 adrenoceptor antagonist that does not discriminate between α1 subtypes. Inhibits increases in intraurethral pressure caused by phenylephrine-induced contraction by 81% with minor cardiovascular effects. Also relaxes corpus cavernosum tissue (pIC50 = 7.64) in vitro.

Technical Data

M.Wt:
425.91
Formula:
C19H27N5O4.HCl
Solubility:
Soluble to 25 mM in water and to 25 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
81403-68-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Yamaguchi et al (2005) Effects of different alpha-1 adrenoceptor blockers on proximal urethral function using in vivo isovolumetric pressure changes. J.Smooth Muscle Res. 41 247. PMID: 16428864.

Lee (2003) Alfuzosin hydrocholride for the treatment of benign prostatic hyperplasia. Am.J.Health Syst.Pharm. 60 1426. PMID: 12892027.

Palea and Barras (2003) Comparison of the relaxant effects of alfuzosin, phentolamine and sildenafil on rabbit isolated corpus cavernosum. BJU Int. 91 873. PMID: 12780851.

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Keywords: Alfuzosin hydrochloride, supplier, Uroselective, α1-adrenoceptor, alpha1-adrenoceptor, a1-adrenoceptor, a1-adrenergic, antagonists, α1-adrenergic, alpha1-adrenergic, Receptors, Tocris Bioscience, Adrenergic α1 Receptor Antagonist products

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