Cat. No. 3305
Chemical Name: N-[3-[(4-Amino-6,7-dimethoxy-2-quin
Biological ActivityFunctionally uro-selective α1 adrenoceptor antagonist that does not discriminate between α1 subtypes. Inhibits increases in intraurethral pressure caused by phenylephrine-induced contraction by 81% with minor cardiovascular effects. Also relaxes corpus cavernosum tissue (pIC50 = 7.64) in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Yamaguchi et al (2005) Effects of different alpha-1 adrenoceptor blockers on proximal urethral function using in vivo isovolumetric pressure changes. J.Smooth Muscle Res. 41 247. PMID: 16428864.
Lee (2003) Alfuzosin hydrocholride for the treatment of benign prostatic hyperplasia. Am.J.Health Syst.Pharm. 60 1426. PMID: 12892027.
Palea and Barras (2003) Comparison of the relaxant effects of alfuzosin, phentolamine and sildenafil on rabbit isolated corpus cavernosum. BJU Int. 91 873. PMID: 12780851.
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Keywords: Alfuzosin hydrochloride, supplier, Uroselective, α1-adrenoceptor, alpha1-adrenoceptor, a1-adrenoceptor, a1-adrenergic, antagonists, α1-adrenergic, alpha1-adrenergic, Receptors, Tocris Bioscience, Adrenergic α1 Receptor Antagonist products
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Selective, high affinity, non-competitive α1A adrenoceptor antagonist
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