SU 16f

Cat. No. 3304

SU 16f C24H22N2O3 [251356-45-3]

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Chemical Name: 5-[1,2-Dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid

Biological Activity

Potent and selective platelet-derived growth factor receptor β (PDGFRβ) inhibitor (IC50 = 10 nM) that displays > 14-fold, > 229-fold and > 10000-fold selectivity over VEGFR2, FGFR1 and EGFR respectively. Inhibits proliferation of HUVEC and NIH3T3 cells in vitro (IC50 = 0.11 μM).

Technical Data

M.Wt:
386.44
Formula:
C24H22N2O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at RT
CAS No:
251356-45-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Sun et al (1999) Design, synthesis, and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF, and PDGF receptor tyrosine kinases. J.Med.Chem. 42 5120. PMID: 10602697.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for SU 16f include:

Lee et al (2014) Lymphatic endothelial cells support tumor growth in breast cancer. Sci Rep 4 5853. PMID: 25068296.

Do you know of a great paper that uses SU 16f from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: SU 16f, supplier, Potent, selective, PDGFRβ, PDGFRbeta, PDGFRb, inhibitors, inhibits, Platelet, Derived, Growth, Factor, Receptors, Tyrosine, Kinases, RTKs, SU16f, Tocris Bioscience, PDGFR Inhibitor products

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