UVI 3003

Cat. No. 3303

UVI 3003 C28H36O4 [847239-17-2]

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Chemical Name: 3-[4-Hydroxy-3-[5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-(pentyloxy)-2-naphthalenyl]phenyl]-2-propenoic acid

Biological Activity

RXR antagonist; displays high RXR binding affinity. Does not affect the corepressor interaction capacity of the RARα subunit within the context of the RAR-RXR heterodimer.

Technical Data

M.Wt:
436.58
Formula:
C28H36O4
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
847239-17-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Le Maire et al (2009) Activation of RXR-PPAR heterodimers by organotin environmental endocrine disruptors. EMBO Rep. 10 367. PMID: 19270714.

Santin et al (2009) Modulating retinoid X receptor with a series of (E)-3-[4-Hydroxy-3-(3-alkoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]acrylic acids and their 4-alkoxy isomers. J.Med.Chem. 52 3150. PMID: 19408900.

Nahoum et al (2007) Modulators of the stuctural dynamics of the retinoid X receptor to reveal receptor function. Proc.Natl.Acad.Sci. 104 17323.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for UVI 3003 include:

Porcu et al (2015) Clobetasol and Halcinonide Act as Smoothened Agonists to Promote Myelin Gene Expression and RxRγ Receptor Activation. PLoS One 10 e0144550. PMID: 26658258.

Marconett et al (2013) Integrated transcriptomic and epigenomic analysis of primary human lung epithelial cell differentiation. PLoS Genet 9 e1003513. PMID: 23818859.

Cambray et al (2012) Activin induces cortical interneuron identity and differentiation in embryonic stem cell-derived telencephalic neural precursors. Nat Commun 3 841. PMID: 22588303.

Do you know of a great paper that uses UVI 3003 from Tocris? If so please let us know.

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Keywords: UVI 3003, supplier, UVI3003, rxr, retinoid, x, receptors, antagonists, Tocris Bioscience, Retinoid X Receptor Antagonist products

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