NU 6140

Cat. No. 3301

NU 6140 C23H30N6O2 [444723-13-1]

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Chemical Name: 4-[[6-(Cyclohexylmethoxy)-1H-purin-2-yl]amino]-N,N-diethylbenzamide

Biological Activity

Cyclin-dependent kinase 2 (cdk2) inhibitor; induces cell-cycle arrest at the G2-M phase. 10- to 36-fold more selective for cdk2-cyclin A over other cdks (IC50 = 0.41 μM for cdk2-cyclin A). Potentiates the apoptotic effect of taxol (Cat. No. 1097) in HeLa cells; down-regulates the antiapoptotic protein survivin.

Technical Data

M.Wt:
422.52
Formula:
C23H30N6O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
444723-13-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Pennati et al (2005) Potentiation of paclitaxel-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation. Mol.Cancer.Ther. 4 1328. PMID: 16170024.

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Keywords: NU 6140, supplier, NU6140, cdk2, inhibitor, cyclin-dependent, kinase, inhibitors, inhibits, anti-apoptotic, arrests, cell, cycle, Tocris Bioscience, Cyclin-Dependent Protein Kinase Inhibitor products

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