NGD 94-1

Cat. No. 3298

NGD 94-1 C18H20N6 [178928-68-2]

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Chemical Name: 2-[4-[(2-Phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]-pyrimidine

Biological Activity

High affinity D4 receptor ligand; selective over D1, D2, D3 and D5 receptors. Displays antagonist activity at the human D4.2 receptor (Ki = 3.6 nM in transfected CHO cells) and exhibits agonist activity at the D4.4 receptor in HEK 293 cells.

Technical Data

M.Wt:
320.39
Formula:
C18H20N6
Solubility:
Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
178928-68-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Gazi et al (1999) NGD 94-1 as an agonist at human recombinant dopamine D4.4 receptors expressed in HEK293 cells. Eur.J.Pharmacol. 372 R9. PMID: 10395031.

Primus et al (1997) II. Localization and characterization of dopamine D4 binding sites in rat and human brain by use of the novel, D4 receptor-selective ligand [3H]NGD 94-1. J.Pharmacol.Exp.Ther. 282 1020. PMID: 9262371.

Tallman et al (1997) I. NGD 94-1: Identification of a novel, high affinity antagonist at the human dopamine D4 receptor. J.Pharmacol.Exp.Ther. 282 1011. PMID: 9262370.

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Keywords: NGD 94-1, supplier, NGD941, antagonist, dopamine, receptors, D4, D4.2, dopaminergic, ligand, receptor, Tocris Bioscience, D4 Receptor Ligand products

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