Cat. No. 3298
Chemical Name: 2-[4-[(2-Phenyl-1H-imidazol-5-yl)me
Biological ActivityHigh affinity D4 receptor ligand; selective over D1, D2, D3 and D5 receptors. Displays antagonist activity at the human D4.2 receptor (Ki = 3.6 nM in transfected CHO cells) and exhibits agonist activity at the D4.4 receptor in HEK 293 cells.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Gazi et al (1999) NGD 94-1 as an agonist at human recombinant dopamine D4.4 receptors expressed in HEK293 cells. Eur.J.Pharmacol. 372 R9. PMID: 10395031.
Primus et al (1997) II. Localization and characterization of dopamine D4 binding sites in rat and human brain by use of the novel, D4 receptor-selective ligand [3H]NGD 94-1. J.Pharmacol.Exp.Ther. 282 1020. PMID: 9262371.
Tallman et al (1997) I. NGD 94-1: Identification of a novel, high affinity antagonist at the human dopamine D4 receptor. J.Pharmacol.Exp.Ther. 282 1011. PMID: 9262370.
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