SSR 146977 hydrochloride
Cat. No. 3297
Chemical Name: N1-[1-3-[(3R)-1-Benzoyl-3-(3-(3,4-d
Biological ActivityPotent and selective NK3 receptor antagonist (Ki values are 0.26 and 19.3 nM in CHO cells expressing the human NK3 and NK2 receptor respectively). Also inhibits senktide-induced inositol monophosphate formation and intracellular calcium mobilization (IC50 = 10 nM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Emonds-Alt et al (2002) Biochemical and pharmacological activities of SSR 146977, a new potent nonpeptide tachykinin NK3 receptor antagonist. Can.J.Physiol.Pharmacol. 80 482. PMID: 12056557.
If you know of a relevant reference for SSR 146977 hydrochloride please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses SSR 146977 hydrochloride from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: SSR 146977 hydrochloride, supplier, tachykinin, neurokinin, receptors, nk3, neuropeptides, antagonists, SSR146977, Tocris Bioscience, NK3 Receptor Antagonist products
Find multiple products by catalog number
November 8 - 10, 2017