CGP 37157

Cat. No. 1114

CGP 37157 C15H11Cl2NOS [75450-34-9]

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Chemical Name: 7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one

Biological Activity

Selective antagonist of the mitochondrial Na+-Ca2+ exchanger (IC50 = 0.4 μM).

Technical Data

Soluble to 100 mM in DMSO
>99 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Baron and Thayer (1997) CGP37157 modulates mitochondrial Ca2+ homeostasis in cultured rat dorsal root ganglion neurons. Eur.J.Pharmacol. 340 295. PMID: 9537826.

White and Reynolds (1997) Mitochondria accumulate Ca2+ following intense glutamate stimulation of cultured rat forebrain neurones. J.Physiol. 498 31. PMID: 9023766.

Cox et al (1993) Selectivity of inhibition of Na+-Ca2+ exchange of heart mitochondria by benzothiazepine CGP-37157. J.Cardiovasc.Pharmacol. 21 595. PMID: 7681905.

Cox and Matlib (1993) Modulation of intramitochondrial free Ca2+ concentration by antagonists of Na+-Ca2+ exchange. TiPS 14 408. PMID: 8296399.

If you know of a relevant reference for CGP 37157 please let us know.

Citations are publications that use Tocris products. Selected citations for CGP 37157 include:

Lin et al (2015) Palmitoylethanolamide inhibits glutamate release in rat cerebrocortical nerve terminals. Elife 16 5555. PMID: 25768340.

Pecze et al (2015) Routes of Ca2+ Shuttling during Ca2+ Oscillations: FOCUS ON THE ROLE OF MITOCHONDRIAL Ca2+ HANDLING AND CYTOSOLIC Ca2+ BUFFERS. World J Gastroenterol 290 28214. PMID: 26396196.

Yang et al (2015) Mitochondrial Ca2+ and membrane potential, an alternative pathway for Interleukin 6 to regulate CD4 cell effector function. J Biol Chem 4. PMID: 25974216.

Pandit et al (2012) Na delivery and ENaC mediate flow regulation of collecting duct endothelin-1 production. Am J Physiol Renal Physiol 302 F1325. PMID: 22357920.

Midkiff et al (2011) Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways. PLoS One 6 e25395. PMID: 21966518.

Zhdanov et al (2011) Bafilomycin A1 activates respiration of neuronal cells via uncoupling associated with flickering depolarization of mitochondria. Cell Mol Life Sci 68 903. PMID: 20820851.

Kim et al (2006) Involvement of mitochondrial Na+-Ca2+ exchange in intestinal pacemaking activity. J Biol Chem 12 796. PMID: 16521198.

Schild et al (2003) Brain mitochondria are primed by moderate Ca2+ rise upon hypoxia/reoxygenation for functional breakdown and morphological disintegration. Am J Physiol Heart Circ Physiol 278 25454. PMID: 12702720.

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Keywords: CGP 37157, supplier, Antagonists, mitochondrial, Na+/Ca2+, Exchanger, Ca2+, Signaling, Signalling, Calcium, Sodium, Ion, Transporters, Pumps, CGP37157, NCX, Tocris Bioscience, Na+/Ca2+ Exchanger Inhibitor products

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