CGP 37157

Cat. No. 1114

CGP 37157 C15H11Cl2NOS [75450-34-9]

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Chemical Name: 7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one

Biological Activity

Selective antagonist of the mitochondrial Na+-Ca2+ exchanger (IC50 = 0.4 μM).

Technical Data

Soluble to 100 mM in DMSO
>99 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Baron and Thayer (1997) CGP37157 modulates mitochondrial Ca2+ homeostasis in cultured rat dorsal root ganglion neurons. Eur.J.Pharmacol. 340 295. PMID: 9537826.

White and Reynolds (1997) Mitochondria accumulate Ca2+ following intense glutamate stimulation of cultured rat forebrain neurones. J.Physiol. 498 31. PMID: 9023766.

Cox et al (1993) Selectivity of inhibition of Na+-Ca2+ exchange of heart mitochondria by benzothiazepine CGP-37157. J.Cardiovasc.Pharmacol. 21 595. PMID: 7681905.

Cox and Matlib (1993) Modulation of intramitochondrial free Ca2+ concentration by antagonists of Na+-Ca2+ exchange. TiPS 14 408. PMID: 8296399.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for CGP 37157 include:

Pandit et al (2012) Na delivery and ENaC mediate flow regulation of collecting duct endothelin-1 production. Am J Physiol Renal Physiol 302 F1325. PMID: 22357920.

Midkiff et al (2011) Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways. PLoS One 6 e25395. PMID: 21966518.

Zhdanov et al (2011) Bafilomycin A1 activates respiration of neuronal cells via uncoupling associated with flickering depolarization of mitochondria. Cell Mol Life Sci 68 903. PMID: 20820851.

Do you know of a great paper that uses CGP 37157 from Tocris? If so please let us know.

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Keywords: CGP 37157, supplier, Antagonists, mitochondrial, Na+/Ca2+, Exchanger, Ca2+, Signaling, Signalling, Calcium, Sodium, Ion, Transporters, Pumps, CGP37157, NCX, Tocris Bioscience, Na+/Ca2+ Exchanger Inhibitor products

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