Cat. No. 1112
Chemical Name: (1R,3R,4S)-1-Aminocyclopentane-1,3,
Biological ActivityCompetitive metabotropic receptor antagonist (KB values are 115, 88 and 77 μM at mGlu1a, mGlu2 and mGlu4a respectively).
Licensing InformationSold with the permission of the CNRS
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Bessis et al (2002) Closure of the venus flytrap model of mGlu8 receptor and the activation process: Insights from mutations converting antagonists into agonists. Proc.Natl.Acad.Sci.U.S.A. 99 11097. PMID: 12151600.
Acher et al (1997) Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes. J.Med.Chem. 40 3119. PMID: 9301676.
If you know of a relevant reference for ACPT-II please let us know.
Citations are publications that use Tocris products. Selected citations for ACPT-II include:
Casado et al (2000) Presynaptic N-methyl-D-aspartate receptors at the parallel fiber-Purkinje cell synapse. Int J Mol Sci 97 11593. PMID: 11016958.
Do you know of a great paper that uses ACPT-II from Tocris? If so please let us know.
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Keywords: ACPT-II, supplier, Competitive, receptor, antagonists, Non-Selective, Receptors, Metabotropic, Glutamate, Tocris Bioscience, Non-selective Metabotropic Glutamate Antagonist products
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