Cat. No. 1112
Chemical Name: (1R,3R,4S)-1-Aminocyclopentane-1,3,
Biological ActivityCompetitive metabotropic receptor antagonist (KB values are 115, 88 and 77 μM at mGlu1a, mGlu2 and mGlu4a respectively).
Licensing InformationSold with the permission of the CNRS
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Bessis et al (2002) Closure of the venus flytrap model of mGlu8 receptor and the activation process: Insights from mutations converting antagonists into agonists. Proc.Natl.Acad.Sci.U.S.A. 99 11097. PMID: 12151600.
Acher et al (1997) Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes. J.Med.Chem. 40 3119. PMID: 9301676.
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Citations are publications that use Tocris products. Selected citations for ACPT-II include:
Casado et al (2000) Presynaptic N-methyl-D-aspartate receptors at the parallel fiber-Purkinje cell synapse. Int J Mol Sci 97 11593. PMID: 11016958.
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Keywords: ACPT-II, supplier, Competitive, receptor, antagonists, Non-Selective, Receptors, Metabotropic, Glutamate, Tocris Bioscience, Non-selective Metabotropic Glutamate Antagonist products
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