Cat. No. 3295
Chemical Name: N-Phthalyl-L-tryptophan
Biological ActivityNon-nucleoside DNA methyltransferase inhibitor that blocks the enzyme active site. Inhibits DNA methylation in human cancer cell lines in vitro without detectable toxicity. Demethylates and reactivates epigenetically silenced tumor suppressor genes. Enhances the efficiency of induced pluripotent stem cell (iPS) generation.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Schirrmacher et al (2006) Synthesis and in vitro evaluation of biotinylated RG108: a high affinity compound for studying binding interactions with human DNA methyltransferases. Bioconjug.Chem. 17 261. PMID: 16536454.
Stresemann et al (2006) Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines. Cancer Res. 66 2794. PMID: 16510601.
Brueckner et al (2005) Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of DNA methyltransferase. Cancer Res. 65 6305. PMID: 16024632.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for RG 108 include:
Zhang et al (2016) Pharmacological reprogramming of fibroblasts into neural stem cells by signaling-directed transcriptional activation. Cell Stem Cell 18 653. PMID: 27133794.
Do you know of a great paper that uses RG 108 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: RG 108, supplier, Non-nucleoside, DNA, methyltransferase, inhibitor, inhibitors, transferases, RG108, inhibits, DNA, methylation, dnmt, epigenetics, Tocris Bioscience, DNA Methyltransferase Inhibitor products
Find multiple products by catalog number
New Products in this Area
Carnitine palmitoyltransferase 1 and 2 (CPT1/2) inhibitorMS 023 dihydrochloride
Potent and selective type I PRMT inhibitorP-3FAX-Neu5Ac
Sialic acid analog; sialyltransferase inhibitorTolcapone
COMT inhibitor; also inhibits transthyretin aggregationJNJ DGAT2-A
DGAT2 inhibitorLLY 507
Potent SMYD2 inhibitorEML 425
Reversible and non-competitive p300/CBP inhibitorMI 2 dihydrochloride
Menin-MLL interaction inhibitor
November 12 - 16, 2016
San Diego, CA, USA