SN 003

Cat. No. 3294

SN 003 C19H25N5O2 [197801-88-0]

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Chemical Name: N-(4-Methoxy-2-methylphenyl)-1-[1-(methoxymethyl)propyl]-6-methyl-1H-1,2,3-triazolo[4,5-c]pyridin-4-amine

Biological Activity

Reversible corticotropin releasing factor receptor 1 (CRF1) antagonist (Ki values are 3.4 and 7.9 nM at rat and human CRF1 respectively) that displays >1000-fold selectivity over CRF2 receptors. Suppresses CRF-induced ACTH release in vitro (IC50 = 241 nM) and is brain penetrant.

Technical Data

M.Wt:
355.43
Formula:
C19H25N5O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
197801-88-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Sullivan et al (2007) PET imaging of CRF1 with [11C]R121920 and [11C]DMP696: Is the target of sufficient density? Nucl.Med.Biol 34 353. PMID: 17499724.

Kumar et al (2006) Synthesis and in vivo evaluation of [11C]SN003 as a PET ligand for CRF1 receptors. Bioorg.Med.Chem. 14 4029. PMID: 16529935.

Zhang et al (2003) Pharmacological characterization of a novel nonpeptide antagonist radioligand, (±)-N-[2-Methyl-4-methoxyphenyl]-1-(1-(methoxymethyl) propyl)-6-methyl-1H-1,2,3-triazolo[4,5-c]pyridin-4-amine ([3H]SN003) for corticotropin-releasing factor1 receptors. J.Pharm.Exp.Ther. 305 57.

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Keywords: SN 003, supplier, reversible, corticotropin, releasing, factor, receptors, 1, CRF1, CRF, antagonists, SN003, Tocris Bioscience, CRF1 Receptor Antagonist products

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