m-Chlorophenylbiguanide hydrochloride

Cat. No. 0440

m-Chlorophenylbiguanide hydrochloride C8H10ClN5.HCl [2113-05-5]

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Chemical Name: 1-(3-Chlorophenyl)biguanide hydrochloride

Biological Activity

Prototypical potent and selective 5-HT3 receptor agonist.

Technical Data

Soluble to 100 mM in water
>98 %
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Niemeyer and Lummis (1998) Different efficacy of specific agonists at 5-HT3 receptor splice variants: the role of the extra six amino acid segment. Br.J.Pharmacol. 123 661. PMID: 9517385.

Boess et al (1992) 5HT3 receptors in NG108-15 neuroblastoma X glioma cells: effect of the novel agonist 1-(m-chlorophenyl)biguanide. Neuropharmacology 31 561. PMID: 1407396.

Sepulveda et al (1991) The agonist properties of m-chlorophenylbiguanide and 2-methyl-5-hydroxytryptamine on 5-HT3 receptors in N1E-115 neuroblastoma cells. Br.J.Pharmacol. 104 536. PMID: 1797317.

Kilpatrick et al (1990) 1-(m-Chlorophenyl)biguanide, a potent high affinity 5-HT3 receptor agonist. Eur.J.Pharmacol. 182 193. PMID: 2144822.

If you know of a relevant reference for m-Chlorophenylbiguanide hydrochloride please let us know.

Citations are publications that use Tocris products. Selected citations for m-Chlorophenylbiguanide hydrochloride include:

Dale et al (2014) Vortioxetine disinhibits pyramidal cell function and enhances synaptic plasticity in the rat hippocampus. J Psychopharmacol 28 891. PMID: 25122043.

Schulz et al (2012) First and second generation antipsychotics influence hippocampal gamma oscillations by interactions with 5-HT3 and D3 receptors. Br J Pharmacol 167 1480. PMID: 22817643.

Huang et al (2009) Autocrine and paracrine roles for ATP and serotonin in mouse taste buds. PLoS One 29 13909. PMID: 19890001.

Gill et al (2008) Serotonin modifies cytoskeleton and brush-border membrane architecture in human intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol 295 G700. PMID: 18669621.

Do you know of a great paper that uses m-Chlorophenylbiguanide hydrochloride from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: m-Chlorophenylbiguanide hydrochloride, supplier, Potent, selective, specific, 5-HT3, agonists, Serotonin, Receptors, Tocris Bioscience, 5-HT3 Receptor Agonist products

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5-HT Scientific Review

Written by N. Barnes & J. Neumaler

5-HT Receptors Scientific Review

Our 5-HT review summarizes the serotonin receptor subtypes and highlights their importance in mediating various physiological & pharmacological processes. Request copy or view PDF today.

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