p-Chlorophenylalanine

Cat. No. 0938

p-Chlorophenylalanine C9H10ClNO2 [7424-00-2]

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Biological Activity

Binds irreversibly to tryptophan hydroxylase to cause depletion of serotonin in the brain.

Technical Data

M.Wt:
199.64
Formula:
C9H10ClNO2
Solubility:
Soluble to 10 mM in 1eq. NaOH and to 5 mM in water with gentle warming
Purity:
>99 %
Storage:
Store at RT
CAS No:
7424-00-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Datla and Curzon (1996) Effect of p-chlorophenylalanine at moderate dosage on 5-HT and 5-HIAA concentrations in brain regions of control and p-chloroamphetamine treated rats. Neuropharmacology 35 315. PMID: 8783206.

Koyuncuoglu et al (1975) The effects of DL-p-chlorophenylalanine and DL-α-methyl-p-tyrosine on the brain catecholamine, serotonin and free amino acid contents in rat. Psychopharmacologia 45 163. PMID: 129787.

If you know of a relevant reference for p-Chlorophenylalanine please let us know.

Citations are publications that use Tocris products. Selected citations for p-Chlorophenylalanine include:

Tullius et al (2014) NAD+ protects against EAE by regulating CD4+ T-cell differentiation. Nat Commun 5 5101. PMID: 25290058.

Hernandez et al (2012) Mammary gland serotonin regulates parathyroid hormone-related protein and other bone-related signals. Proc Natl Acad Sci U S A 302 E1009. PMID: 22318950.

Do you know of a great paper that uses p-Chlorophenylalanine from Tocris? If so please let us know.

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Keywords: p-Chlorophenylalanine, supplier, Tryptophan, hydroxylases, inhibitors, inhibits, serotonin, depletion, PCPA, fenclonine, Tocris Bioscience, Hydroxylase Inhibitor products

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