p-Chlorophenylalanine

Cat. No. 0938

p-Chlorophenylalanine C9H10ClNO2 [7424-00-2]

Price and Availability

For p-Chlorophenylalanine pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Biological Activity

Binds irreversibly to tryptophan hydroxylase to cause depletion of serotonin in the brain.

Technical Data

M.Wt:
199.64
Formula:
C9H10ClNO2
Solubility:
Soluble to 10 mM in 1eq. NaOH and to 5 mM in water with gentle warming
Purity:
>99 %
Storage:
Store at RT
CAS No:
7424-00-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Datla and Curzon (1996) Effect of p-chlorophenylalanine at moderate dosage on 5-HT and 5-HIAA concentrations in brain regions of control and p-chloroamphetamine treated rats. Neuropharmacology 35 315. PMID: 8783206.

Koyuncuoglu et al (1975) The effects of DL-p-chlorophenylalanine and DL-α-methyl-p-tyrosine on the brain catecholamine, serotonin and free amino acid contents in rat. Psychopharmacologia 45 163. PMID: 129787.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for p-Chlorophenylalanine include:

Tullius et al (2014) NAD+ protects against EAE by regulating CD4+ T-cell differentiation. Nat Commun 5 5101. PMID: 25290058.

Hernandez et al (2012) Mammary gland serotonin regulates parathyroid hormone-related protein and other bone-related signals. Proc Natl Acad Sci U S A 302 E1009. PMID: 22318950.

Do you know of a great paper that uses p-Chlorophenylalanine from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: p-Chlorophenylalanine, supplier, Tryptophan, hydroxylases, inhibitors, inhibits, serotonin, depletion, PCPA, fenclonine, Tocris Bioscience, Hydroxylase Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

New Product Guide

New Product Guide (Fall/Winter 2016)

Our New Product guide highlights over 100 new products added in the second half of 2016. Request copy or view PDF today.

divider line

New Products in this Area

PF 04449613

Potent PDE9 inhibitor; brain penetrant

Eggmanone

Potent and selective PDE4 inhibitor; suppresses hedgehog signaling

Adaptaquin

HIF-prolyl hydroxylase-2 (PHD2) inhibitor; antioxidant

Sign-up for new product e-alerts
divider line

Bio-Techne Events

ASCB 2016

ASCB 2016

December 3 - 7, 2016

San Francisco, CA,

Booth: 314