Chlorisondamine diiodide

Cat. No. 1001

Chlorisondamine diiodide C14H20Cl4I2N2 [96750-66-2]

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Alternative Name: 3-[[4-(Chlorophenyl)piperazin-1-yl]methyl-1H-pyrrolo[2,3-b]pyridine diiodide

Chemical Name: 4,5,6,7-Tetrachloro-1,3-dihydro-2-methyl-2-[2-trimethylammonium)ethyl]-2H-isoindolium diiodide

Biological Activity

An exceptionally long lasting nicotinic antagonist (IC50 ~ 1.6 mM); blockade of central nicotinic responses induced by chlorisondamine can persist for several weeks.

Technical Data

Soluble to 10 mM in water
>99 %
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Clarke et al (1994) The pharmacology of the nicotinic antagonist, chlorisondamine investigated in rat brain and autonomic ganglion. Br.J.Pharmacol. 111 397. PMID: 7911713.

El-Bizri and Clarke (1994) Blockade of nicotinic receptor-mediated release of dopamine from striatal synaptosomes by chlorisondamine and other nicotinic antagonists administered in vitro. Br.J.Pharmacol. 111 406. PMID: 8004384.

El-Bizri and Clarke (1994) Regulation of nicotinic receptors in rat brain following quasi-irreversible nicotinic blockade by chlorisondamine and chronic treatment with nicotine. Br.J.Pharmacol. 113 917. PMID: 7858886.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Chlorisondamine diiodide include:

Sabharwal et al (2015) Angiotensin-dependent autonomic dysregulation precedes dilated cardiomyopathy in a mouse model of muscular dystrophy. J Exp Med 100 776. PMID: 25921929.

Sabharwal et al (2014) Chronic oral administration of Ang-(1-7) improves skeletal muscle, autonomic and locomotor phenotypes in muscular dystrophy. J Cereb Blood Flow Metab 127 101. PMID: 24502705.

Luyer et al (2005) Nutritional stimulation of cholecystokinin receptors inhibits inflammation via the vagus nerve. Clin Sci (Lond) 202 1023. PMID: 16216887.

Do you know of a great paper that uses Chlorisondamine diiodide from Tocris? If so please let us know.

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Keywords: Chlorisondamine diiodide, supplier, Nicotinic, antagonists, slow, offset, Acetylcholine, Receptors, Non-Selective, nAChR, Tocris Bioscience, Nicotinic Receptor (Non-selective) Antagonist products

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