Chlorisondamine diiodide

Cat. No. 1001

Chlorisondamine diiodide C14H20Cl4I2N2 [96750-66-2]

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Alternative Name: 3-[[4-(Chlorophenyl)piperazin-1-yl]methyl-1H-pyrrolo[2,3-b]pyridine diiodide

Chemical Name: 4,5,6,7-Tetrachloro-1,3-dihydro-2-methyl-2-[2-trimethylammonium)ethyl]-2H-isoindolium diiodide

Biological Activity

An exceptionally long lasting nicotinic antagonist (IC50 ~ 1.6 mM); blockade of central nicotinic responses induced by chlorisondamine can persist for several weeks.

Technical Data

M.Wt:
611.95
Formula:
C14H20Cl4I2N2
Solubility:
Soluble to 10 mM in water
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
96750-66-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Clarke et al (1994) The pharmacology of the nicotinic antagonist, chlorisondamine investigated in rat brain and autonomic ganglion. Br.J.Pharmacol. 111 397. PMID: 7911713.

El-Bizri and Clarke (1994) Blockade of nicotinic receptor-mediated release of dopamine from striatal synaptosomes by chlorisondamine and other nicotinic antagonists administered in vitro. Br.J.Pharmacol. 111 406. PMID: 8004384.

El-Bizri and Clarke (1994) Regulation of nicotinic receptors in rat brain following quasi-irreversible nicotinic blockade by chlorisondamine and chronic treatment with nicotine. Br.J.Pharmacol. 113 917. PMID: 7858886.

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Keywords: Chlorisondamine diiodide, supplier, Nicotinic, antagonists, slow, offset, Acetylcholine, Receptors, Non-Selective, nAChR, Tocris Bioscience, Nicotinic Receptor (Non-selective) Antagonist products

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