Cat. No. 3293
Alternative Name: MK 906
Chemical Name: (5α,17β)-N-(1,1-Dimethylethyl)-3-oxo-
Biological ActivityAntiandrogen that inhibits type II 5α reductase (IC50 = 65 nM). Suppresses the conversion of testosterone to dihydrotestosterone. Reduces prostatic dihydrotestosterone levels and prostate size in vivo. Orally active.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Mukai et al (2008) Studies on neurosteroids XXV. Influence of a 5α-reductase inhibitor, finasteride, on rat brain neurosteroid levels and metabolism. Biol.Pharm.Bull. 31 1646. PMID: 18758053.
Gao et al (2004) Comparison of the pharmacological effects of a novel selective androgen receptor modulator, the 5α-reductase inhibitor finasteride, and the antiandrogen hydroxyflutamide in intact rats: new approach for benign prostate hyperplasia. Endocrinology 145 5420. PMID: 15308613.
Thigpen and Russell (1992) Four-amino acid segment in steroid 5α-reductase 1 confers sensitivity to finasteride, a competitive inhibitor. J.Biol.Chem. 267 8577. PMID: 1314830.
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Citations are publications that use Tocris products. Selected citations for Finasteride include:
Ferando and Mody (2013) Altered gamma oscillations during pregnancy through loss of δ subunit-containing GABA(A) receptors on parvalbumin interneurons. Front Neural Circuits 7 144. PMID: 24062647.
Handa et al (2013) Central 5-α reduction of testosterone is required for testosterone's inhibition of the hypothalamo-pituitary-adrenal axis response to restraint stress in adult male rats. Nat Neurosci 1529 74. PMID: 23880372.
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Keywords: Finasteride, supplier, Type, II, 5α-reductases, 5alpha-reductases, inhibitors, inhibits, MK906, Tocris Bioscience, Other Reductase Inhibitor products
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