6-Chloromelatonin

Cat. No. 0443

6-Chloromelatonin C13H15ClN2O2 [63762-74-3]

Price and Availability

For 6-Chloromelatonin pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: N-[2-(6-Chloro-5-methoxyindol-3-yl)ethyl]acetamide

Biological Activity

Potent melatonin agonist (pKi values are 9.10 and 9.77 for human recombinant MT1 and MT2 receptors respectively). Displays higher affinity for binding to hamster brain membrane and chicken retina than melatonin.

Technical Data

M.Wt:
266.73
Formula:
C13H15ClN2O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
63762-74-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis is currently unavailable
on-line. Please contact Customer Service
Safety Data Sheet: View Safety Data Sheet

Browning et al (2000) Pharmacological characterization of human recombinant melatonin mt1 and MT2 receptors. Br.J.Pharmacol. 129 877. PMID: 10696085.

Dubocovich (1995) Melatonin receptors: are there multiple subtypes? TiPS 16 50. PMID: 7762083.

Dubocovich (1988) Luzindole (NO 774): A novel melatonin receptor antagonist. J.Pharmacol.Exp.Ther. 246 902. PMID: 2843633.

Duncan et al (1988) 2-[125I]Iodomelatonin binding sites in hamster brain membranes: pharmacological characteristics and regional distribution. Endocrinology 122 1825. PMID: 2834175.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses 6-Chloromelatonin from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: 6-Chloromelatonin, supplier, Melatonin, agonists, MT, Receptors, Tocris Bioscience, Melatonin Receptor Agonist products

Quick Order

Find multiple products by catalog number

divider line

GPCR Product Listing

GPCR Product Listing

Highlights over 450 products for GPCRs Request copy or view PDF today.

divider line

New Products in this Area

CATPB

FFA2 antagonist/inverse agonist

Oleanolic acid

Selective GPBA receptor (TGR5) partial agonist

PPTN hydrochloride

High affinity and selective P2Y14 antagonist

Itraconazole

SMO antagonist; acts at different binding site to cyclopamine (Cat No. 1623)

SAR 216471 hydrochloride

Potent P2Y12 antagonist; orally available

A 971432

Potent and selective S1P5 agonist

GLPG 0974

Potent FFA2 antagonist

Ogerin

Selective positive allosteric modulator at GPR68

BGC 20-1531 hydrochloride

High affinity and selective EP4 antagonist

Montelukast sodium

CysLT1 and GPR17 antagonist

Sign-up for new product e-alerts
divider line

Bio-Techne Events

Neuroscience 2016

Neuroscience 2016

November 12 - 16, 2016

San Diego, CA, USA

Booth: 3217