7-Chlorokynurenic acid

Cat. No. 0237

7-Chlorokynurenic acid C10H6ClNO3 [18000-24-3]

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Chemical Name: 7-Chloro-4-hydroxyquinoline-2-carboxylic acid

Biological Activity

NMDA receptor antagonist acting at the glycine site. Potent competitive inhibitor of L-glutamate transport into synaptic vesicles. Also available as part of the NMDA Receptor - Glycine Site Tocriset™. 7-Chlorokynurenic acid sodium salt (Cat. No. 3697) also available.

Technical Data

M.Wt:
223.62
Formula:
C10H6ClNO3
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in 1eq. NaOH
Purity:
>98 %
Storage:
Store at RT
CAS No:
18000-24-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis is currently unavailable
on-line. Please contact Customer Service

Bartlett et al (1998) Substituted quinolines as inhibitors of L-glutamate transport into synaptic vesicles. Neuropharmacology 37 839. PMID: 9776380.

Kretschmer et al (1995) Behavioral and neurochemical actions of the strychnine-insensitive glycine receptor antagonist, 7-chlorokynurenate, in rats. Eur.J.Pharmacol. 280 37. PMID: 7498252.

Donald et al (1988) Characterization of [3H]-glycine binding to a modulatory site within the NMDA receptor complex from rat brain. Br.J.Pharmacol. 95 892P.

Kemp et al (1988) 7-Chlorokynurenic acid is a selective antagonist of the glycine modulatory site of the NMDA receptor complex. Proc.Natl.Acad.Sci.U.S.A. 85 6547. PMID: 2842779.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for 7-Chlorokynurenic acid include:

Biase et al (2011) NMDA receptor signaling in oligodendrocyte progenitors is not required for oligodendrogenesis and myelination. Proc Natl Acad Sci U S A 31 12650. PMID: 21880926.

Baltan et al (2008) White matter vulnerability to ischemic injury increases with age because of enhanced excitotoxicity. J Neurosci 28 1479. PMID: 18256269.

Shin et al (2006) Vasoconstrictive neurovascular coupling during focal ischemic depolarizations. J Cereb Blood Flow Metab 26 1018. PMID: 16340958.

Vigot et al (2006) Differential compartmentalization and distinct functions of GABAB receptor variants. Neuron 50 589. PMID: 16701209.

Casado et al (2000) Presynaptic N-methyl-D-aspartate receptors at the parallel fiber-Purkinje cell synapse. Proc Natl Acad Sci U S A 97 11593. PMID: 11016958.

Tacconi et al (1993) Inhibition of [3H]-(+)-MK 801 binding to rat brain sections by CPP and 7-chlorokynurenic acid: an autoradiographic analysis. Br J Pharmacol 108 577. PMID: 8096780.

Do you know of a great paper that uses 7-Chlorokynurenic acid from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: 7-Chlorokynurenic acid, supplier, Potent, competitive, inhibitors, inhibits, L-glutamate, uptake, NMDA, antagonists, glycine, site, EAAT, Excitatory, Amino, Acid, Transporters, GLAST, GLT-1, Glutamate, Monoamine, Neurotransmitter, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, Tocris Bioscience, Glutamate Transporter Inhibitor products

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