Cat. No. 3286
Chemical Name: (1R*,2S*)-2-(Aminomethyl)-N,N-dieth
Biological ActivityOrally active 5-HT and noradrenalin re-uptake inhibitor (SNRI) (IC50 values are 203 and 100 nM respectively) that displays no affinity at a range of other receptors. Causes adaptive changes to α1-adrenergic and 5-HT2A serotonergic systems when administered repeatedly. Exhibits antidepressive and antinociceptive activities in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Suzuki et al (2008) Antiallodynic and antihyperalgesic effect of milnacipran in mice with spinal nerve ligation. Anesth.Analg. 106 1309. PMID: 18349211.
Maj et al (2000) Pharmacological effect of milnacipran, a new antidepressant, given repeatedly on the α1-adrenergic and serotonergic 5-HT2A systems. J.Neural.Transm. 107 1345. PMID: 11145008.
Moret et al (1985) Biochemical profile of midalcipran (F 2207), 1-phenyl-1-diethyl-aminocarbonyl-2-aminomethyl-cyclopropane (z) hydrochloride, a potential fourth generation antidepressant drug. Neuropharmacology 24 1211. PMID: 3005901.
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Citations are publications that use Tocris products. Selected citations for Milnacipran hydrochloride include:
Burnham and Dickenson (2013) The antinociceptive effect of milnacipran in the monosodium iodoacetate model of osteoarthritis pain and its relation to changes in descending inhibition. J Pharmacol Exp Ther 344 696. PMID: 23297162.
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Keywords: Milnacipran hydrochloride, supplier, 5-HT, noradrenaline, reuptake, inhibitors, inhibits, SNRI, Transporters, NET, Adrenergic, Monoamine, Neurotransmitter, Serotonin, SERT, 5-Hydroxytryptamine, Tocris Bioscience, 5-HT Transporter Inhibitor products
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