Rec 15/2615 dihydrochloride
Cat. No. 3284
Chemical Name: 1-(4-Amino-6,7-dimethoxy-2-quinazol
Biological ActivitySelective α1B-adrenoceptor antagonist (Ki values are 0.3, 1.9 and 2.6 nM at human α1B, α1A and α1D receptors respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Morston et al (2007) α1A-adrenoceptors mediate contractions to phenylephrine in rabbit penile arteries. Br.J.Pharmacol. 150 112. PMID: 17115072.
Bremner et al (2000) Ligand design for α1 adrenoceptor subtype selective antagonist. Bioorg.Med.Chem. 8 201. PMID: 10968279.
Testa et al (1997) Pharmacological characterization of the uroselective alpha-1 antagonist Rec 15/2739 (SB 216469): Role of the alpha-1L adrenoceptor in tissue selectivity, part II. J.Pharmacol.Exp.Ther. 281 1284. PMID: 9190864.
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Selective, high affinity, non-competitive α1A adrenoceptor antagonist
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