2-ThioUTP tetrasodium salt
Cat. No. 3280
Chemical Name: 2-Thiouridine 5'-triphosphate tetrasodium salt
Biological ActivityPotent and selective P2Y2 agonist (EC50 values are 0.035, 0.35 and 1.5 μM for hP2Y2, hP2Y4 and hP2Y6 receptors respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Ko et al (2008) Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists. Bioorg.Med.Chem. 16 6319. PMID: 18514530.
El-Tayeb et al (2006) Synthesis and structure-activity relationships of uracil nucleotide derivatives and analogues as agonists at human P2Y2, P2Y4 and P2Y6 receptors. J.Med.Chem. 49 7076. PMID: 17125260.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for 2-ThioUTP tetrasodium salt include:
Alkhani et al (2014) Contribution of TRPC3 to store-operated calcium entry and inflammatory transductions in primary nociceptors. Mol Brain 10 43. PMID: 24965271.
Martín-Gil et al (2012) Silencing of P2Y(2) receptors reduces intraocular pressure in New Zealand rabbits. Br J Pharmacol 165 1163. PMID: 21740413.
Matsumoto et al (2011) Uridine adenosine tetraphosphate-induced contraction is increased in renal but not pulmonary arteries from DOCA-salt hypertensive rats. Am J Physiol Heart Circ Physiol 301 H409. PMID: 21551273.
Do you know of a great paper that uses 2-ThioUTP tetrasodium salt from Tocris? If so please let us know.
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Keywords: 2-ThioUTP tetrasodium salt, supplier, Potent, selective, P2Y2, agonists, Receptors, Purinergic, purinoceptors, Tocris Bioscience, Purinergic (P2Y) Receptor Agonist products
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