Cat. No. 3277
Chemical Name: 4,4'-(Pentamethylenedioxy)dibenzamid
Biological ActivityAntimicrobial. Neuroprotective; inhibits constitutive nitric oxide synthase in the brain and acts as a NMDA glutamate receptor antagonist.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Kitamura et al (1995) Inhibition of constitutive nitric oxide synthase in the brain by pentamidine, a calmodulin antagonist. Eur.J.Pharmacol. 289 299. PMID: 7542607.
Reynolds and Aizeman (1992) Pentamidine is an N-methyl-D-aspartate receptor antagonist and is neuroprotective in vitro. J.Neurosci. 12 970. PMID: 1532027.
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Citations are publications that use Tocris products. Selected citations for Pentamidine isethionate include:
Capoccia et al (2015) S100B-p53 disengagement by pentamidine promotes apoptosis and inhibits cellular migration via aquaporin-4 and metalloproteinase-2 inhibition in C6 glioma cells. Oncol Lett 9 2864. PMID: 26137161.
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Keywords: Pentamidine isethionate, supplier, Antimicrobial, inhibits, inhibitors, constitutive, nNOS, NMDA, antagonist, receptors, Nitric, Oxide, Signaling, Signalling, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, Neuronal, oxide, Synthases, Tocris Bioscience, NMDA Receptor Antagonist products
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