Mephenytoin

Cat. No. 3276

Mephenytoin C12H14N2O2 [50-12-4]

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Chemical Name: (±)-5-Ethyl-3-methyl-5-phenyl-2,4-imidazolidinedione

Biological Activity

CYP2C19 and CYP2B6 substrate. Anticonvulsant.

Technical Data

M.Wt:
218.25
Formula:
C12H14N2O2
Solubility:
Soluble to 20 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
50-12-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Foti et al (2008) CYP2C19 inhibition: the impact of substrate probe selection on in vitro inhibition profiles. Drug Meta. Dispos. 36 523. PMID: 18048485.

Tamminga et al (2001) Mephenytoin as a probe for CYP2C19 phenotyping: effect of sample storage, intra-individual reproducibility and occurrence of adverse events. Br.J.Clin.Pharmacol. 51 471. PMID: 11422005.

Knabe and Wunn (1980) Racemic and optically active hydantoins from disubstituted cyanoacetic acids. Arch.Pharmacol. 313 53.

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Keywords: Mephenytoin, supplier, CYP2C19, Anticonvulsant, Cytochrome, P450, Tocris Bioscience, Cytochrome P450 Substrate products

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