(±)-LY 395756

Cat. No. 3272

()-LY 395756 C9H13NO4 [852679-66-4]

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Chemical Name: (1S,2S,4R,5R,6S)-rel-2-Amino-4-methylbicyclo[3.1.0]hexane-2,6-dicarboxylic acid

Biological Activity

Selective metabotropic glutamate ligand for mGlu2 and mGlu3 receptors (Ki values are 0.165 μM and 0.302 μM respectively). Acts as an agonist at mGlu2 and antagonist at mGlu3. Analog of LY 354740 (Cat. No. 3246).

Technical Data

M.Wt:
199.21
Formula:
C9H13NO4
Solubility:
Soluble to 100 mM in 1eq. HCl and to 100 mM in 1eq. NaOH
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
852679-66-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

Dominguez et al (2005) Methyl substitution of 2-aminobicyclo[3.1.0]hexane 2,6-dicarboxylate (LY354740) determines functional activity at metabotropic glutamate receptors: identification of a subtype selective mGlu2 receptor agonist. J.Med.Chem. 48 3605. PMID: 15887967.

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Keywords: ()-LY 395756, supplier, LY395756, agonist, metabotropic, glutamate, ligand, receptor, receptors, mGlu2, mGlu3, Tocris Bioscience, Glutamate (Metabotropic) Group II Receptor Agonist products

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