Cat. No. 1109
Chemical Name: 4'-Acetyl-N-[4-[4-(2-methoxyphenyl)-
Biological ActivityA potent and selective dopamine D3 receptor antagonist, with a Ki value of 0.3 nM and > 100- fold selectivity over D2 and D4 sites.
Licensing InformationSold with the permission of GlaxoSmithKline
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Audinot et al (1998) A comparative in vitro and in vivo pharmacological characterization of the novel dopamine D3 receptor antagonists (+)-S 14297, nafadotride, GR 103,691 and U 99194. J.Pharmacol.Exp.Ther. 287 187. PMID: 9765337.
Hurley et al (1996) Dopamine D3 receptors are not involved in the induction of c-fos mRNA by neuroleptic drugs: comparison of the dopamine D3 receptor antagonist GR 103691 with the typical and atypical neuroleptics. Eur.J.Pharmacol. 318 283. PMID: 9016916.
Murray et al (1995) A novel series of arylpiperazines with high affinity and selectivity for the dopamine D3 receptor. Bioorg.Med.Chem.Lett. 5 219.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for GR 103691 include:
Lee et al (2015) Dopaminergic effects on in vitro osteogenesis. Mol Cancer 3 15020. PMID: 26558139.
Wang et al (2015) A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in dopamine D2 and D3 receptor agonist-induced autophagy activation. Bone Res 11 2057. PMID: 26649942.
Diaz et al (2014) Moderate Alcohol Exposure during the Rat Equivalent to the Third Trimester of Human Pregnancy Alters Regulation of GABAA Receptor-Mediated Synaptic Transmission by Dopamine in the Basolateral Amygdala. Autophagy 2 46. PMID: 24904907.
Clemens and Hochman (2004) Conversion of the modulatory actions of dopamine on spinal reflexes from depression to facilitation in D3 receptor knock-out mice. J Neurosci 24 11337. PMID: 15601940.
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Keywords: GR 103691, supplier, selective, D3, antagonists, Dopamine, Receptors, dopaminergic, GR103691, GlaxoSmithKline, GSK, Tocris Bioscience, D3 Receptor Antagonist products
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April 10 - 13, 2017