GR 103691

Cat. No. 1109

GR 103691 C30H35N3O3 [162408-66-4]

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Chemical Name: 4'-Acetyl-N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-[1,1'-biphenyl]-4-carboxamide

Biological Activity

A potent and selective dopamine D3 receptor antagonist, with a Ki value of 0.3 nM  and > 100- fold selectivity over D2 and D4 sites.

Licensing Information

Sold with the permission of GlaxoSmithKline

Technical Data

M.Wt:
485.63
Formula:
C30H35N3O3
Solubility:
Soluble to 10 mM in DMSO with gentle warming
Storage:
Store at RT
CAS No:
162408-66-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Audinot et al (1998) A comparative in vitro and in vivo pharmacological characterization of the novel dopamine D3 receptor antagonists (+)-S 14297, nafadotride, GR 103,691 and U 99194. J.Pharmacol.Exp.Ther. 287 187. PMID: 9765337.

Hurley et al (1996) Dopamine D3 receptors are not involved in the induction of c-fos mRNA by neuroleptic drugs: comparison of the dopamine D3 receptor antagonist GR 103691 with the typical and atypical neuroleptics. Eur.J.Pharmacol. 318 283. PMID: 9016916.

Murray et al (1995) A novel series of arylpiperazines with high affinity and selectivity for the dopamine D3 receptor. Bioorg.Med.Chem.Lett. 5 219.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for GR 103691 include:

Clemens and Hochman (2004) Conversion of the modulatory actions of dopamine on spinal reflexes from depression to facilitation in D3 receptor knock-out mice. J Neurosci 24 11337. PMID: 15601940.

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Keywords: GR 103691, supplier, selective, D3, antagonists, Dopamine, Receptors, dopaminergic, GR103691, GlaxoSmithKline, GSK, Tocris Bioscience, D3 Receptor Antagonist products

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