Compound 401

Cat. No. 3271

Compound 401 C16H15N3O2 [168425-64-7]

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Chemical Name: 2-(4-Morpholinyl)-4H-pyrimido[2,1-a]isoquinolin-4-one

Biological Activity

Reversible and selective inhibitor of DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR) (IC50 values are 0.28 and 5.3 μM respectively). Displays little affinity for other commonly studied kinases including PI 3-K, ATM and ATR (IC50 values are all > 100 μM). Induces apoptosis in vitro.

Technical Data

M.Wt:
281.31
Formula:
C16H15N3O2
Solubility:
Soluble to 10 mM in DMSO and to 5 mM in ethanol
Purity:
>99 %
Storage:
Store at RT
CAS No:
168425-64-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Ballo et al (2007) Inhibition of mammalian target of rapamycin signaling by 2-(morpholin-1-yl)oyrimido[2,1-α]isoquinolin-4-one. J.Biol.Chem. 282 24463. PMID: 17562705.

Griffen et al (2005) Selective benzopyranone and pyrimido[2,1-α]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies and radiosensitization of a human tumor cell line in vitro. J.Med.Chem. 48 569. PMID: 15658870.

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Keywords: Compound 401, supplier, Selective, DNA-PK, mTOR, inhibitors, inhibits, Checkpoint, Control, Kinases, DNA-Dependent, Protein, Kinase, PI3K, Phosphoinositide, PI, 3-kinase, Akt, Signaling, Signalling, Mammalian, Target, Rapamycin, FRAP, Compound401, Tocris Bioscience, DNA-Dependent Protein Kinase Inhibitor products

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