Cat. No. 3271
Chemical Name: 2-(4-Morpholinyl)-4H-pyrimido[2,1-a
Biological ActivityReversible and selective inhibitor of DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR) (IC50 values are 0.28 and 5.3 μM respectively). Displays little affinity for other commonly studied kinases including PI 3-K, ATM and ATR (IC50 values are all > 100 μM). Induces apoptosis in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Ballo et al (2007) Inhibition of mammalian target of rapamycin signaling by 2-(morpholin-1-yl)oyrimido[2,1-α]isoquinolin-4-one. J.Biol.Chem. 282 24463. PMID: 17562705.
Griffen et al (2005) Selective benzopyranone and pyrimido[2,1-α]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies and radiosensitization of a human tumor cell line in vitro. J.Med.Chem. 48 569. PMID: 15658870.
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Keywords: Compound 401, supplier, Selective, DNA-PK, mTOR, inhibitors, inhibits, Checkpoint, Control, Kinases, DNA-Dependent, Protein, Kinase, PI3K, Phosphoinositide, PI, 3-kinase, Akt, Signaling, Signalling, Mammalian, Target, Rapamycin, FRAP, Compound401, Tocris Bioscience, DNA-Dependent Protein Kinase Inhibitor products
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