Cat. No. 3268
Chemical Name: [4S-(4α,4aα,5aα,12aα)]-4,7-Bis(dimethyl
Biological ActivityTetracycline antibiotic. Displays neuroprotective, antiapoptotic, anti-inflammatory and antimicrobial effects. Acts as a matrix metalloproteinase (MMP) inhibitor; attenuates disease severity in mouse models of multiple sclerosis. Orally active and brain penetrant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Padi and Kulkarni (2008) Minocycline prevents the development of neuropathic pain, but not acute pain: possible anti-inflammatory and antioxidant mechanisms. Eur.J.Pharmacol. 601 79. PMID: 18952075.
Brundula et al (2002) Targeting leukocyte MMPs and transmigration: Minocycline as a potential therapy for multiple sclerosis. Brain 125 1297. PMID: 12023318.
Tikka et al (2001) Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia. J.Neurosci. 21 2580. PMID: 11306611.
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Citations are publications that use Tocris products. Selected citations for Minocycline hydrochloride include:
Song et al (2015) Minocycline does not affect long-term potentiation in the anterior cingulate cortex of normal adult mice. Hum Mol Genet 11 25. PMID: 25933605.
Yaeger and Trussell (2015) Single granule cells excite Golgi cells and evoke feedback inhibition in the cochlear nucleus. J Neurosci 35 4741. PMID: 25788690.
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Keywords: Minocycline hydrochloride, supplier, Minocycline, HCl, antibiotics, MMP, matrix, metalloproteinase, inhibitors, inhibits, neuroprotective, Tocris Bioscience, Antibiotic products
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