Minocycline hydrochloride

Cat. No. 3268

Minocycline hydrochloride C23H27N3O7.HCl [13614-98-7]

Price and Availability

For Minocycline hydrochloride pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: [4S-(4α,4aα,5aα,12aα)]-4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a,tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide

Biological Activity

Tetracycline antibiotic. Displays neuroprotective, antiapoptotic, anti-inflammatory and antimicrobial effects. Acts as a matrix metalloproteinase (MMP) inhibitor; attenuates disease severity in mouse models of multiple sclerosis. Orally active and brain penetrant.

Technical Data

M.Wt:
493.94
Formula:
C23H27N3O7.HCl
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in water
Purity:
>98 %
Storage:
Desiccate at +4°C
CAS No:
13614-98-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

Padi and Kulkarni (2008) Minocycline prevents the development of neuropathic pain, but not acute pain: possible anti-inflammatory and antioxidant mechanisms. Eur.J.Pharmacol. 601 79. PMID: 18952075.

Brundula et al (2002) Targeting leukocyte MMPs and transmigration: Minocycline as a potential therapy for multiple sclerosis. Brain 125 1297. PMID: 12023318.

Tikka et al (2001) Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia. J.Neurosci. 21 2580. PMID: 11306611.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Minocycline hydrochloride include:

Yaeger and Trussell (2015) Single granule cells excite Golgi cells and evoke feedback inhibition in the cochlear nucleus. J Neurosci 35 4741. PMID: 25788690.

Do you know of a great paper that uses Minocycline hydrochloride from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: Minocycline hydrochloride, supplier, Minocycline, HCl, antibiotics, MMP, matrix, metalloproteinase, inhibitors, inhibits, neuroprotective, Tocris Bioscience, Antibiotic products

Quick Order

Find multiple products by catalog number

divider line

New Product Guide

New Product Guide (Spring/Summer 2016)

Our New Product guide highlights over 110 new products added in the first half of 2016. View PDF today.

divider line

New Products in this Area

Trolox

Antioxidant vitamin E derivative

NBD 556

CD4 mimetic; blocks HIV-1 cell entry

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.