Minocycline hydrochloride

Cat. No. 3268

Minocycline hydrochloride C23H27N3O7.HCl [13614-98-7]

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Chemical Name: [4S-(4α,4aα,5aα,12aα)]-4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a,tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide

Biological Activity

Tetracycline antibiotic. Displays neuroprotective, antiapoptotic, anti-inflammatory and antimicrobial effects. Acts as a matrix metalloproteinase (MMP) inhibitor; attenuates disease severity in mouse models of multiple sclerosis. Orally active and brain penetrant.

Technical Data

M.Wt:
493.94
Formula:
C23H27N3O7.HCl
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in water
Purity:
>98 %
Storage:
Desiccate at +4°C
CAS No:
13614-98-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Padi and Kulkarni (2008) Minocycline prevents the development of neuropathic pain, but not acute pain: possible anti-inflammatory and antioxidant mechanisms. Eur.J.Pharmacol. 601 79. PMID: 18952075.

Brundula et al (2002) Targeting leukocyte MMPs and transmigration: Minocycline as a potential therapy for multiple sclerosis. Brain 125 1297. PMID: 12023318.

Tikka et al (2001) Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia. J.Neurosci. 21 2580. PMID: 11306611.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Minocycline hydrochloride include:

Song et al (2015) Minocycline does not affect long-term potentiation in the anterior cingulate cortex of normal adult mice. Hum Mol Genet 11 25. PMID: 25933605.

Yaeger and Trussell (2015) Single granule cells excite Golgi cells and evoke feedback inhibition in the cochlear nucleus. J Neurosci 35 4741. PMID: 25788690.

Do you know of a great paper that uses Minocycline hydrochloride from Tocris? If so please let us know.

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Keywords: Minocycline hydrochloride, supplier, Minocycline, HCl, antibiotics, MMP, matrix, metalloproteinase, inhibitors, inhibits, neuroprotective, Tocris Bioscience, Antibiotic products

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