Cat. No. 3267
Biological ActivityAntibiotic that inhibits bacterial protein synthesis. Inhibits mRNA-tRNA translocation by GTPase elongation factor G (EF-G), EF-TU(GTP)-catalyzed aa-tRNA delivery and the activity of initiation factor 2 (IF-2). Antitumor agent; induces cell cycle arrest and apoptosis in breast cancer cells via downregulation of FOXM1 expression.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Kwok et al (2008) Thiostrepton selectively targets breast cancer cells through inhibition of forkhead box M1 expression. Mol.Cancer Ther. 7 2022. PMID: 18645012.
Ruben et al (2007) Thiostrepton inhibition of tRNA delivery to the ribosome. RNA 13 2091. PMID: 17951333.
Rodnina et al (1999) Thiostrepton inhibits the turnover but not the GTPase of elongation factor G on the ribosome. Proc.Natl.Acad.Sci.USA 96 9586.
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Citations are publications that use Tocris products. Selected citations for Thiostrepton include:
Uddin et al (2011) Genome-wide expression analysis of Middle Eastern colorectal cancer reveals FOXM1 as a novel target for cancer therapy. Am J Pathol 178 537. PMID: 21281787.
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Keywords: Thiostrepton, supplier, Downregulates, FOXM1, Antibiotics, inhibits, inhibitors, Hh, Signaling, Signalling, Hedgehog, Transcription, Factors, protein, synthesis, Tocris Bioscience, DNA, RNA and Protein Synthesis Inhibitor products
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