GLP-1 (9-36) amide

Cat. No. 3266

GLP-1 (9-36) amide Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-NH2

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Alternative Name: Glucagon-like peptide 1 (9-36) amide

Biological Activity

N-terminal truncated metabolite of glucagon-like peptide GLP-1-(7-36) (Cat. No. 2082) formed by dipeptidyl peptidase-IV cleavage. Acts as an antagonist at the human GLP-1 receptor. Inhibits hepatic glucose production in vivo and is a weak insulinotropic agent.

Technical Data

M.Wt:
3089.44
Formula:
C140H214N36O43
Sequence:
EGTFTSDVSSYLEGQAAKEFIAWLVKGR

(Modifications: Arg-28 = C-terminal amide)

Solubility:
Soluble to 2 mg/ml in 0.025% acetic acid
Storage:
Desiccate at -20°C
CAS No:
161748-29-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Elahi et al (2008) GLP-1 (9-36) amide, cleavage product of GLP-1 (7-36) amide is a glucoregulatory peptide. Obesity 16 1501. PMID: 18421270.

Knudsen and Pridal (1996) Glucagon-like peptide-1-(9-36) amide is a major metabolite of glucagon-like peptide-1-(7-36) amide after in vivo administration to dogs, and it acts as an antagonist on the pancreatic receptor. Eur.J.Pharmacol. 318 429. PMID: 9016935.

Deacon et al (1995) Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo. J.Clin.Endocrinol.Met. 80 952.

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Keywords: GLP-1 (9-36) amide, supplier, Metabolite, GLP-1-7-36, GLP1, Receptors, Glucagon-Like, Peptide, 1, Glucagon, like, peptide1, (9-36), amide, diabetes, Tocris Bioscience, Glucagon-Like Peptide 1 Receptor Antagonist products

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