GLP-1 (9-36) amide
Cat. No. 3266
Alternative Name: Glucagon-like peptide 1 (9-36) amide
Biological ActivityN-terminal truncated metabolite of glucagon-like peptide GLP-1-(7-36) (Cat. No. 2082) formed by dipeptidyl peptidase-IV cleavage. Acts as an antagonist at the human GLP-1 receptor. Inhibits hepatic glucose production in vivo and is a weak insulinotropic agent.
(Modifications: Arg-28 = C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Elahi et al (2008) GLP-1 (9-36) amide, cleavage product of GLP-1 (7-36) amide is a glucoregulatory peptide. Obesity 16 1501. PMID: 18421270.
Knudsen and Pridal (1996) Glucagon-like peptide-1-(9-36) amide is a major metabolite of glucagon-like peptide-1-(7-36) amide after in vivo administration to dogs, and it acts as an antagonist on the pancreatic receptor. Eur.J.Pharmacol. 318 429. PMID: 9016935.
Deacon et al (1995) Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo. J.Clin.Endocrinol.Met. 80 952.
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Keywords: GLP-1 (9-36) amide, supplier, Metabolite, GLP-1-7-36, GLP1, Receptors, Glucagon-Like, Peptide, 1, Glucagon, like, peptide1, (9-36), amide, diabetes, Tocris Bioscience, Glucagon-Like Peptide 1 Receptor Antagonist products