SB 452533

Cat. No. 3265

SB 452533 C18H22BrN3O [459429-39-1]

Price and Availability

For SB 452533 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Special Conditions

No more than 500 mg per individual per year to be sold without prior permission from the licence holder.

Chemical Name: N-(2-Bromophenyl)-N'-[2-[ethyl(3-methylphenyl)amino]ethyl]-urea

Biological Activity

Potent TRPV1 antagonist against capsaicin (pKb = 7.7), noxious heat and acid-mediated (pIC50 = 7.0) receptor activation (pKi = 6.22 at the recombinant hTRPV1 receptor). Exhibits analgesic properties.

Licensing Information

Sold for research purposes only under agreement from GlaxoSmithKline

Technical Data

M.Wt:
376.29
Formula:
C18H22BrN3O
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol with gentle warming
Purity:
>98 %
Storage:
Store at RT
CAS No:
459429-39-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Bianchi et al (2007) [3H]A-778317 [1-((R)-5-tert-Butyl-indan-1-yl)-3-isoquinolin-5-ylurea]: a novel, stereoselective, high-affinity antagonist is a useful radioligand for the human transient receptor potential vanilloid-1 (TRPV1) receptor. J.Pharmacol.Exp.Ther. 323 285. PMID: 17660385.

Weil et al (2005) Conservation of functional and pharmacological properties in the distantly related temperature sensors TRPV1 and TRPM8. Mol.Pharmacol. 68 518. PMID: 15911692.

Rami et al (2004) Discovery of small molecule antagonists of TRPV1. Bioorg.Med.Chem.Lett. 14 3631. PMID: 15203132.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for SB 452533 include:

Vijayvergiya et al (2015) Measurement of Ensemble TRPV1 Ion Channel Currents Using Droplet Bilayers. Mol Pain 10 e0141366. PMID: 26513481.

Do you know of a great paper that uses SB 452533 from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: SB 452533, supplier, SB452533, TRPV1, transient, receptor, potential, channels, antagonists, vanilloid, receptors, analgesic, analgaesic, Tocris Bioscience, TRPV Antagonist products

Quick Order

Find multiple products by catalog number

divider line

Pain Research Product Guide

Pain Research Product Guide

Our Pain guide highlights over 280 products for Pain research. Request copy or view PDF today.

divider line

Peripheral Sensitization

Written by Grant D. Nicol and Michael R. Vasko

Pain Life Science Poster

Our Peripheral Sensitization poster gives a summary of the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. Request copy or view PDF today.

divider line

New Products in this Area

AMG 517

Potent TRPV1 antagonist

PF 05105679

Selective TRPM8 blocker

M 084 hydrochloride

TRPC4/5 channel blocker; antidepressant and anxiolytic

A 425619

Potent TRPV1 antagonist

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.